ZNF530
Zinc finger protein 530
Also known as: KIAA1508, ZN530_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P9A1
- Gene
- ZNF530
- Ensembl
- ENSG00000183647
- Chromosome
- 19
- Canonical length
- 599 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Vesicles
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
599 residues, UniProt reviewed canonical sequence.
>Q6P9A1|ZNF530
1 MAAALRAPTQ QVFVAFEDVA IYFSQEEWEL LDEMQRLLYR DVMLENFAVM ASLGCWCGAV
61 DEGTPSAESV SVEELSQGRT PKADTSTDKS HPCEICTPVL RDILQMIELH ASPCGQKLYL
121 GGASRDFWMS SNLHQLQKLD NGEKLFKVDG DQASFMMNCR FHVSGKPFTF GEVGRDFSAT
181 SGLLQHQVTP TIERPHSRIR HLRVPTGRKP LKYTESRKSF REKSVFIQHQ RADSGERPYK
241 CSECGKSFSQ SSGFLRHRKA HGRTRTHECS ECGKSFSRKT HLTQHQRVHT GERPYDCSEC
301 GKSFRQVSVL IQHQRVHTGE RPYECSECGK SFSHSTNLYR HRSAHTSTRP YECSECGKSF
361 SHSTNLFRHW RVHTGVRPYE CSECGKAFSC NIYLIHHQRF HTGERPYVCS ECGKSFGQKS
421 VLIQHQRVHT GERPYECSEC GKVFSQSSGL FRHRRAHTKT KPYECSECEK SFSCKTDLIR
481 HQTVHTGERP YECSVCGKSF IRKTHLIRHQ TVHTNERPYE CDECGKSYSQ SSALLQHRRV
541 HTGERPYECR ECGKSFTRKN HLIQHKTVHT GERPYECSEC GKSFSQSSGL LRHRRVHVQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF530 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 5.9 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 5.9 nTPM
- cerebellum: 3.4 nTPM
- heart muscle: 3.4 nTPM
- retina: 3.2 nTPM
- bone marrow: 2.8 nTPM
- cerebral cortex: 2.6 nTPM
Single-cell type
- thymic myoid cells: 19 nCPM
- oocytes: 14 nCPM
- erythrocyte progenitors: 9.4 nCPM
- müller glia: 6.4 nCPM
- megakaryocyte progenitors: 6 nCPM
- differentiating spermatogonia: 5.2 nCPM
Immune cell
- NK-cell: 2.2 nTPM
- memory B-cell: 1.9 nTPM
- neutrophil: 1.7 nTPM
- T-reg: 1.6 nTPM
- naive CD8 T-cell: 1.4 nTPM
- memory CD8 T-cell: 1.3 nTPM
Brain region
- cerebellum: 18 nTPM
- choroid plexus: 14 nTPM
- white matter: 13 nTPM
- cerebral cortex: 12 nTPM
- hippocampal formation: 11 nTPM
- medulla oblongata: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.83
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.11
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF530 as an antibody target. Whether an autoantibody or antibody against ZNF530 could matter depends on whether native ZNF530 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF530 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF530 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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