Seroatlas · Human Serome Atlas

ZNF527

Zinc finger protein 527

Also known as: KIAA1829, ZN527_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NB42
Gene
ZNF527
Ensembl
ENSG00000189164
Chromosome
19
Canonical length
609 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear speckles,Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

609 residues, UniProt reviewed canonical sequence.

>Q8NB42|ZNF527
     1  MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LKPSQKDLYR DVMLENYRNL VWLGLSISKP
    61  NMISLLEQGK EPWMVERKMS QGHCADWESW CEIEELSPKW FIDEDEISQE MVMERLASHG
   121  LECSSFREAW KYKGEFELHQ GNAERHFMQV TAVKEISTGK RDNEFSNSGR SIPLKSVFLT
   181  QQKVPTIQQV HKFDIYDKLF PQNSVIIEYK RLHAEKESLI GNECEEFNQS TYLSKDIGIP
   241  PGEKPYESHD FSKLLSFHSL FTQHQTTHFG KLPHGYDECG DAFSCYSFFT QPQRIHSGEK
   301  PYACNDCGKA FSHDFFLSEH QRTHIGEKPY ECKECNKAFR QSAHLAQHQR IHTGEKPFAC
   361  NECGKAFSRY AFLVEHQRIH TGEKPYECKE CNKAFRQSAH LNQHQRIHTG EKPYECNQCG
   421  KAFSRRIALT LHQRIHTGEK PFKCSECGKT FGYRSHLNQH QRIHTGEKPY ECIKCGKFFR
   481  TDSQLNRHHR IHTGERPFEC SKCGKAFSDA LVLIHHKRSH AGEKPYECNK CGKAFSCGSY
   541  LNQHQRIHTG EKPYECSECG KAFHQILSLR LHQRIHAGEK PYKCNECGNN FSCVSALRRH
   601  QRIHNRETL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF527 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
2.9 nTPM

Expression across tissuesHPA

Tissue

  • retina: 2.9 nTPM
  • tongue: 2.8 nTPM
  • parathyroid gland: 2.5 nTPM
  • ovary: 2.3 nTPM
  • thymus: 2.3 nTPM
  • thyroid gland: 2.3 nTPM

Single-cell type

  • cardiomyocytes: 29 nCPM
  • sertoli cells: 19 nCPM
  • rod photoreceptor cells: 17 nCPM
  • myonuclei: 15 nCPM
  • hepatic stellate cells: 13 nCPM
  • thyrotrophs: 13 nCPM

Immune cell

  • naive CD8 T-cell: 3.7 nTPM
  • memory B-cell: 3.6 nTPM
  • eosinophil: 3.3 nTPM
  • gdT-cell: 3.3 nTPM
  • memory CD8 T-cell: 3 nTPM
  • MAIT T-cell: 2.9 nTPM

Brain region

  • white matter: 6.3 nTPM
  • cerebral cortex: 6.1 nTPM
  • hypothalamus: 6.1 nTPM
  • medulla oblongata: 6 nTPM
  • cerebellum: 5.9 nTPM
  • pons: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
1.02
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF527 as an antibody target. Whether an autoantibody or antibody against ZNF527 could matter depends on whether native ZNF527 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF527 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF527 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF527. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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