Seroatlas · Human Serome Atlas

ZNF525

Zinc finger protein 525

Also known as: KIAA1979, ZN525_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N782
Gene: ZNF525
Ensembl: ENSG00000203326
Chromosome: 19
Canonical length: 479 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q8N782|ZNF525
     1  MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLGIS SKCTMKEFSS
    61  TAQGNTEVIH TGTLQRHERH HIGDFSFQEI EKDIHNFEFQ WQEDERNGHE APMTKIKKLM
   121  GSTEQYDHRH AGNKPIKYQL GSSFHSHLSE LHIFQPKGKI NNQVEKSIND ASSVSTAQRI
   181  SCRPKTHISN NYGDNFLNYS LLTQRQEVRM REKSFQCIES GKAFNYSSLL RKHQIIHLGE
   241  KQYKCDVCDK VFIRKRYLAR HRRCHTGEKP YKCNECGKSF SQMSSLTYHH RLHTGEKPYK
   301  CEECDKAFRH NSALQRHRRI HTGEKPHKCN ECGKTFSQKS YLACHRSIHT GKKPYECEEC
   361  DKAFSFKSNL ESHRITHTGE KPYKCNDCGK TFSHMSTLTC HRRLHTGEKP YKCEECDEAF
   421  RFKSSLERHR RIHNGEKLYK CNECGKTFSQ ELSLTCHCRL HSGEKPCKCG ECDKAYSFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF525 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 13 nTPM
testis: 8.2 nTPM
skin: 7.9 nTPM
lymph node: 7.4 nTPM
ovary: 6.7 nTPM
prostate: 6.6 nTPM

Single-cell type

syncytiotrophoblasts: 30 nCPM
early spermatids: 30 nCPM
b-cells: 19 nCPM
distal convoluted tubule cells: 17 nCPM
urothelial cells: 17 nCPM
pancreatic acinar cells: 16 nCPM

Immune cell

memory B-cell: 3.5 nTPM
NK-cell: 3.2 nTPM
eosinophil: 3 nTPM
MAIT T-cell: 2.8 nTPM
naive CD4 T-cell: 2.7 nTPM
basophil: 2.6 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 12 nTPM
choroid plexus: 11 nTPM
pons: 9.9 nTPM
cerebral cortex: 9.4 nTPM
medulla oblongata: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0.23
gnomAD missense Z: 0.38

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF525 as an antibody target. Whether an autoantibody or antibody against ZNF525 could matter depends on whether native ZNF525 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF525 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF525 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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