Seroatlas · Human Serome Atlas

ZNF524

Zinc finger protein 524

Also known as: MGC23143, ZN524_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96C55
Gene: ZNF524
Ensembl: ENSG00000171443
Chromosome: 19
Canonical length: 264 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q96C55|ZNF524
     1  MDTPSPDPLP SPLPGEEEKP LALSPPVPRG RRGRRPGGAT SSNRTLKASL PRKRGRPPKS
    61  GQEPPLVQVQ GVTAPVGSSG GSDLLLIDDQ GVPYTVSEGS AAGPEGSGPR KAPHFCPVCL
   121  RAFPYLSDLE RHSISHSELK PHQCKVCGKT FKRSSHLRRH CNIHAGLRPF RCPLCPRRFR
   181  EAGELAHHHR VHSGERPYQC PICRLRFTEA NTLRRHAKRK HPEAMGVPLC APDPGSEPPW
   241  DEEGIPATAG AEEEEETEGK GEPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF524 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

pancreas: 66 nTPM
skeletal muscle: 44 nTPM
skin: 36 nTPM
stomach: 33 nTPM
liver: 28 nTPM
spleen: 27 nTPM

Single-cell type

esophageal apical cells: 141 nCPM
enterocytes: 86 nCPM
paneth cells: 85 nCPM
colonocytes: 73 nCPM
gastric chief cells: 67 nCPM
epididymal principal cells: 66 nCPM

Immune cell

classical monocyte: 24 nTPM
T-reg: 22 nTPM
intermediate monocyte: 21 nTPM
eosinophil: 20 nTPM
myeloid DC: 19 nTPM
naive CD4 T-cell: 16 nTPM

Brain region

medulla oblongata: 22 nTPM
white matter: 22 nTPM
midbrain: 18 nTPM
basal ganglia: 18 nTPM
spinal cord: 18 nTPM
cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0.08
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF524 as an antibody target. Whether an autoantibody or antibody against ZNF524 could matter depends on whether native ZNF524 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF524 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF524 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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