Seroatlas · Human Serome Atlas

ZNF519

Zinc finger protein 519

Also known as: FLJ36809, HsT2362, ZN519_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TB69
Gene
ZNF519
Ensembl
ENSG00000175322
Chromosome
18
Canonical length
540 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q8TB69|ZNF519
     1  MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAVYSYYN QGILPEQGIQ
    61  DSFKKATLGR YGSCGLENIC LWKNWESIGE GEGQKECYNL CSQYLTTSHN KHLTVKGDKE
   121  YRIFQKKPQF LSAAPTEPCI PMNKYQHKFL KSVFCNKNQI NFNHDSNISK HHSTHFLENY
   181  YNCNECEKVF YQSSKLIFPE NIHIQKKPYN SNECGETSDP FSKLTQHQRI YIGESSQRCN
   241  KKCIIVFSQS HLKGHKIINT GEKSVKYKER GKAFTRGLHL GHQKIHTGEK PYKCKKCDKA
   301  FNKSSHLAQH QRIHTGEKPF KCKECGKAFN RGSYLTQHQR IHTGERAFKC EECGKAFNRG
   361  SYLTQHQRIH TGEKPFRCKE CGKAFNRSSY VTQHQRMHTG EKPFKCKECG KAFNRASHLT
   421  QHQRIHTGEK HFKCKECGKA FNRGSHLTRH QRIHTGEKSF KCEECGKAFI WGSHLTQHQR
   481  VHTGEKFFKC KECGKAFTRS SHLTQHQRIH TGEKPFKCKE CGKAFNRRST LTQHQIIHTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF519 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
4.8 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 4.8 nTPM
  • colon: 1.8 nTPM
  • cervix: 1.7 nTPM
  • endometrium: 1.6 nTPM
  • ovary: 1.4 nTPM
  • esophagus: 1.2 nTPM

Single-cell type

  • fibro-adipogenic progenitors: 75 nCPM
  • brain excitatory neurons: 69 nCPM
  • esophageal apical cells: 63 nCPM
  • brain inhibitory neurons: 62 nCPM
  • myonuclei: 58 nCPM
  • oligodendrocyte progenitor cells: 38 nCPM

Immune cell

  • naive CD4 T-cell: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • memory B-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • T-reg: 0.2 nTPM

Brain region

  • cerebellum: 3 nTPM
  • cerebral cortex: 1.4 nTPM
  • white matter: 1.1 nTPM
  • basal ganglia: 0.9 nTPM
  • pons: 0.9 nTPM
  • hippocampal formation: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.01
gnomAD missense Z
-0.78
DepMap mean gene effect
0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF519 as an antibody target. Whether an autoantibody or antibody against ZNF519 could matter depends on whether native ZNF519 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF519 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF519 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF519. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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