Seroatlas · Human Serome Atlas

ZNF518B

Zinc finger protein 518B

Also known as: KIAA1729, Z518B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0D4
Gene: ZNF518B
Ensembl: ENSG00000178163
Chromosome: 4
Canonical length: 1074 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1074 residues, UniProt reviewed canonical sequence.

>Q9C0D4|ZNF518B
     1  MKDIGQQLYT THLNGGHNSL TMSPKQPDAN GAPRPNRQEA QTLLYQGSEA EAAMMTIATC
    61  AKCKSVHKIS LQDLQKGTGK DGMYVCFQCS LGAAPPNFHF VSNNSSATHV GNKTENFSSS
   121  VNSKFKVRNF KPGKYYCDKC RFSTKDPLQY KKHTLQHEEI KFICSHCSYI SYTKGEFQRH
   181  LVKHTGIFPY QCEYCDYGAI RNDYIVKHTK RVHERAGAKR PVKAVAKLEP KRTGTSKQNP
   241  ELLKASNPRT TFQNKWSDQL SGFSLHANKD KMHNIMLLPE PKEYQKDVVC IPNKMTLSEP
   301  NEVNLFENKN VEVEVLSPAK EPVQPGMPLT VVAPAELVVP ANCLAQLIDV KVVNGTQQLV
   361  LKLFPLEENN CLEAGRDNGG NSERMVKEKG SNEQEKVLSA EKTKSLTVDG NVGKLVGIDS
   421  FQPSVQKQLK NVKWVRSYDF IMPNSSVHNN GKSFINSETI EDFQKKNNLY PHRTAFPSVA
   481  LKGHSLASVF KNSVLRSLGA ASNPFPYKAA VCFAESGRNL HSSSQQLLPF AASPATCSFS
   541  GEKGLLPVSE NDLESTSKVN IPVKVVSSNR KQEDNQTEEH KAVSTVGQIS SQHKSEYLHI
   601  NITGEDRSQQ PGDKPLELKN SERTNNTNDG PVISSVFSLS SGSENVPEGI KWNSSTSKIK
   661  SIELLRRKIA QLIESCGKPS SLASNSAHRR SVGQASKGTS KATSEGIQEI NVSLTGLGHS
   721  TGTLQKPPND GGITGNRQLT HQQIYPHFAD GSNRKTKSRV ARKAHVATPV LIPKGAVLRV
   781  LNSSENAHII EATCEAPVSI PCSERQLIKP VPFCPVRQAD SDLQPLRSER GPIDMSPNIE
   841  TPLRPKLRKE SAVCSTIHRK TGLLYGQQGS SELNKQGRLL SRSLSISRNK TKQVHLSRKK
   901  NKIQAEPSRC LKDPSIFQVA RQLRLIAAKP DQLIKCPRRN QPVIVLNHPD VDSPEVTNVM
   961  KVINKYKGNV LKVVLSERTR CQLGIRRHHV RLTYQNAEEA SQIKRQMMLK MKLKKVHKNN
  1021  YQVVDSLPDD SSQCVFKCWF CGRLYEDQEE WMSHGQRHLI EATRDWDVLS SKGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF518B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

testis: 8.4 nTPM
tongue: 8.2 nTPM
tonsil: 8.1 nTPM
thymus: 8 nTPM
thyroid gland: 7.4 nTPM
salivary gland: 6.9 nTPM

Single-cell type

late spermatids: 84 nCPM
megakaryocytes: 31 nCPM
late primary spermatocytes: 30 nCPM
megakaryocyte-erythroid progenitors: 25 nCPM
basal prostatic cells: 24 nCPM
corticotrophs: 23 nCPM

Immune cell

eosinophil: 9.6 nTPM
memory B-cell: 7.9 nTPM
NK-cell: 5 nTPM
neutrophil: 4.9 nTPM
non-classical monocyte: 4.7 nTPM
myeloid DC: 3.5 nTPM

Brain region

cerebellum: 24 nTPM
hypothalamus: 24 nTPM
hippocampal formation: 19 nTPM
cerebral cortex: 19 nTPM
basal ganglia: 18 nTPM
choroid plexus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0
gnomAD missense Z: -1.92
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF518B as an antibody target. Whether an autoantibody or antibody against ZNF518B could matter depends on whether native ZNF518B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF518B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF518B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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