Seroatlas · Human Serome Atlas

ZNF514

Zinc finger protein 514

Also known as: FLJ14457, ZN514_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K75
Gene: ZNF514
Ensembl: ENSG00000144026
Chromosome: 2
Canonical length: 400 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q96K75|ZNF514
     1  MTFEDVAVEF SQWEWGQLNP AQKDLYREVM LENFRNLAIL GLLVSKPYVI CQLEEGGEPF
    61  MVEREISTGA HSDWKRRSKS KESMPSWGIS KEELFQVVSV EKHIQDVLQF SKLKAACGCD
   121  GQLEMQQIKQ ERHLKQMSTI HKSATTLSRD YKWNGFGRSL GLRSVLVNQH SILMGEGSYK
   181  CDTEFRQTLG GNNSQRTHPE KKSCKCNECG KSFHFQSELR RHQRCHTGEK PYECSDCGRA
   241  FGHISSLIKH QRTHTGEKPY ECSECGRAFS QSSSLVLHYR FHTGEKPYKC NECGRAFGHT
   301  SSLIKHQRTH TGEKPYECRE CGRTFSQSSS LIVHYRFHTG EKPYKCNKCG RAFSQSSSLT
   361  QHYRFHTGEK PYKCNECGRA FAHTASLIKH QRSHAGKKTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF514 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

ovary: 25 nTPM
retina: 21 nTPM
cervix: 20 nTPM
thyroid gland: 19 nTPM
epididymis: 19 nTPM
pituitary gland: 19 nTPM

Single-cell type

late spermatids: 29 nCPM
late primary spermatocytes: 23 nCPM
early spermatids: 22 nCPM
oligodendrocytes: 14 nCPM
microglia: 13 nCPM
other brain neurons: 10 nCPM

Immune cell

basophil: 11 nTPM
eosinophil: 7.3 nTPM
naive CD4 T-cell: 7.3 nTPM
naive CD8 T-cell: 6.1 nTPM
naive B-cell: 6 nTPM
memory B-cell: 5.9 nTPM

Brain region

white matter: 17 nTPM
cerebellum: 16 nTPM
cerebral cortex: 16 nTPM
pons: 15 nTPM
hypothalamus: 15 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF514 as an antibody target. Whether an autoantibody or antibody against ZNF514 could matter depends on whether native ZNF514 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF514 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF514 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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