Seroatlas · Human Serome Atlas

ZNF510

Zinc finger protein 510

Also known as: KIAA0972, ZN510_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2H8
Gene
ZNF510
Ensembl
ENSG00000081386
Chromosome
9
Canonical length
683 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a krueppel C2H2-type zinc-finger protein family member. The encoded protein is expressed in several cancer cell types and may be a biomarker for early diagnosis of these cancers. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

683 residues, UniProt reviewed canonical sequence.

>Q9Y2H8|ZNF510
     1  MSPHPEAITD CVTLNTVGQL AEGGYPLRFS TLFQEQQKMN ISQASVSFKD VTIEFTQEEW
    61  QQMAPVQKNL YRDVMLENYS NLVSVGYCCF KPEVIFKLEQ GEEPWFSEEE FSNQSHPKDY
   121  RGDDLIKQNK KIKDKHLEQA ICINNKTLTT EEEKVLGKPF TLHVAAVAST KMSCKCNSWE
   181  VNLQSISEFI INNRNYSTKK IGCGNVCENS PFKINFEKTQ TGEKFYEHNK NMKALNYNEN
   241  LPKHPKFQTL EQAFECNKIG KAFNDKANCV KHNSSHTGET SSKDDEFRKN CDKKTLFDHR
   301  RTGTGKKHLH LNQCGKSFEK STVEEYNKLN MGIKHYELNP SGNNFNRKAH LTDPQTAVIE
   361  ENPLVSNDRT QTWVKSSEYH ENKKSYQTSV HRVRRRSHSM MKPYKCNECG KSFCQKGHLI
   421  QHQRTHTGEK PFECSECGKT FSQKSHLSTH QRIHTAEKPY KCNECGKTFV QKSTLRGHQR
   481  IHTGEKPYEC SECGKTFVQK STLRDHHRIH TGEKSFQCNQ CGKTFGQKSN LRIHQRTHTG
   541  EKTYQCNECE KSFWRKDHLI QHQKTHTGEK PFKCNECGKT FARTSTLRVH QRIHTGEKPF
   601  KCNECGKKFV RKAILSDHQR IHTGEKPFQC NKCGKTFGQK SNLRIHQRTH SGEKSYECNE
   661  YGKLCKKSTL SLYQKIQGEG NPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF510 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • retina: 11 nTPM
  • cerebellum: 8.3 nTPM
  • ovary: 5.3 nTPM
  • pituitary gland: 5.2 nTPM
  • thymus: 5.2 nTPM
  • cerebral cortex: 5.1 nTPM

Single-cell type

  • retinal horizontal cells: 32 nCPM
  • corticotrophs: 32 nCPM
  • lactotrophs: 29 nCPM
  • medullary thymic epithelial cells: 29 nCPM
  • somatotrophs: 29 nCPM
  • thyrotrophs: 28 nCPM

Immune cell

  • NK-cell: 1.4 nTPM
  • naive CD4 T-cell: 1.3 nTPM
  • MAIT T-cell: 1.2 nTPM
  • memory CD4 T-cell: 1.2 nTPM
  • naive B-cell: 1 nTPM
  • memory B-cell: 0.9 nTPM

Brain region

  • cerebellum: 20 nTPM
  • cerebral cortex: 16 nTPM
  • hypothalamus: 14 nTPM
  • white matter: 13 nTPM
  • basal ganglia: 13 nTPM
  • hippocampal formation: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.56
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF510 as an antibody target. Whether an autoantibody or antibody against ZNF510 could matter depends on whether native ZNF510 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF510 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF510 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF510. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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