Seroatlas · Human Serome Atlas

ZNF507

Zinc finger protein 507

Also known as: KIAA1084, Zfp507, ZN507_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCN5
Gene: ZNF507
Ensembl: ENSG00000168813
Chromosome: 19
Canonical length: 953 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

953 residues, UniProt reviewed canonical sequence.

>Q8TCN5|ZNF507
     1  MEESSSVAML VPDIGEQEAI LTAESIISPS LEIDEQRKTK PDPLIHVIQK LSKIVENEKS
    61  QKCLLIGKKR PRSSAATHSL ETQELCEIPA KVIQSPAADT RRAEMSQTNF TPDTLAQNEG
   121  KAMSYQCSLC KFLSSSFSVL KDHIKQHGQQ NEVILMCSEC HITSRSQEEL EAHVVNDHDN
   181  DANIHTQSKA QQCVSPSSSL CRKTTERNET IPDIPVSVDN LQTHTVQTAS VAEMGRRKWY
   241  AYEQYGMYRC LFCSYTCGQQ RMLKTHAWKH AGEVDCSYPI FENENEPLGL LDSSAAAAPG
   301  GVDAVVIAIG ESELSIHNGP SVQVQICSSE QLSSSSPLEQ SAERGVHLSQ SVTLDPNEEE
   361  MLEVISDAEE NLIPDSLLTS AQKIISSSPN KKGHVNVIVE RLPSAEETLS QKRFLMNTEM
   421  EEGKDLSLTE AQIGREGMDD VYRADKCTVD IGGLIIGWSS SEKKDELMNK GLATDENAPP
   481  GRRRTNSESL RLHSLAAEAL VTMPIRAAEL TRANLGHYGD INLLDPDTSQ RQVDSTLAAY
   541  SKMMSPLKNS SDGLTSLNQS NSTLVALPEG RQELSDGQVK TGISMSLLTV IEKLRERTDQ
   601  NASDDDILKE LQDNAQCQPN SDTSLSGNNV VEYIPNAERP YRCRLCHYTS GNKGYIKQHL
   661  RVHRQRQPYQ CPICEHIADN SKDLESHMIH HCKTRIYQCK QCEESFHYKS QLRNHEREQH
   721  SLPDTLSIAT SNEPRISSDT ADGKCVQEGN KSSVQKQYRC DVCDYTSTTY VGVRNHRRIH
   781  NSDKPYRCSL CGYVCSHPPS LKSHMWKHAS DQNYNYEQVN KAINDAISQS GRVLGKSPGK
   841  TQLKSSEESA DPVTGSSENA VSSSELMSQT PSEVLGTNEN EKLSPTSNTS YSLEKISSLA
   901  PPSMEYCVLL FCCCICGFES TSKENLLDHM KEHEGEIVNI ILNKDHNTAL NTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF507 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
thyroid gland: 10 nTPM
tongue: 8.1 nTPM
thymus: 8 nTPM
skeletal muscle: 7.8 nTPM
retina: 7.5 nTPM

Single-cell type

retinal horizontal cells: 94 nCPM
choroid plexus epithelial cells: 76 nCPM
thyrotrophs: 73 nCPM
lactotrophs: 63 nCPM
prostatic glandular cells: 61 nCPM
thymic myoid cells: 61 nCPM

Immune cell

MAIT T-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM
gdT-cell: 1 nTPM
naive B-cell: 1 nTPM
naive CD8 T-cell: 0.9 nTPM
memory CD4 T-cell: 0.8 nTPM

Brain region

white matter: 18 nTPM
cerebellum: 17 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 15 nTPM
midbrain: 15 nTPM
medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.06
gnomAD missense Z: 0.03
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF507 as an antibody target. Whether an autoantibody or antibody against ZNF507 could matter depends on whether native ZNF507 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF507 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF507 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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