Seroatlas · Human Serome Atlas

ZNF506

Zinc finger protein 506

Also known as: DKFZp761G1812, ZN506_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JVG8
Gene: ZNF506
Ensembl: ENSG00000081665
Chromosome: 19
Canonical length: 444 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>Q5JVG8|ZNF506
     1  MGPLQFRDVA IEFSLEEWHC LDAAQRNLYR DVMLENYRNL IFLGIVVSKP NLITCLEQGK
    61  KPLTMKRHEM IAKPPVMYSH FAQDLWSEQS IKDSFQKVIL RRYEKCRHDN LQLKKGCESV
   121  DECPVHKRGY NGLKQCLATT QRKIFQCDEY VKFLHKFSNS NKHKIRDTGK KSFKCIEYGK
   181  TFNQSSTRTT YKKIDAGEKR YKCEECGKAY KQSSHLTTHK KIHTGEKPYK CEECGKAYKQ
   241  SCNLTTHKII HTGEKPYRCR ECGKAFNHPA TLFSHKKIHT GEKPYKCDKC GKAFISSSTL
   301  TKHEIIHTGE KPYKCEECGK AFNRSSNLTK HKRIHTGDVP YKCDECGKTF TWYSSLSKHK
   361  RAHTGEKPYK CEECGKAFTA FSTLTEHKII HTGEKPYKCE ECGKAFNWSS ALNKHKKIHI
   421  RQKPCIVKNV ENLLNVPQPL ISIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF506 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 18 nTPM
skin: 17 nTPM
cerebellum: 15 nTPM
epididymis: 13 nTPM
spleen: 13 nTPM
tonsil: 13 nTPM

Single-cell type

tuft cells: 23 nCPM
corticotrophs: 11 nCPM
gonadotrophs: 8.9 nCPM
somatotrophs: 8.9 nCPM
early spermatids: 8.7 nCPM
hematopoietic stem cells: 8.7 nCPM

Immune cell

naive B-cell: 15 nTPM
naive CD4 T-cell: 14 nTPM
plasmacytoid DC: 14 nTPM
naive CD8 T-cell: 12 nTPM
memory B-cell: 12 nTPM
eosinophil: 9.9 nTPM

Brain region

white matter: 43 nTPM
cerebellum: 37 nTPM
cerebral cortex: 34 nTPM
basal ganglia: 33 nTPM
thalamus: 32 nTPM
medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleolus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF506 as an antibody target. Whether an autoantibody or antibody against ZNF506 could matter depends on whether native ZNF506 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF506 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF506 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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