Seroatlas · Human Serome Atlas

ZNF502

Zinc finger protein 502

Also known as: FLJ12515, FLJ14855, ZN502_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBZ5
Gene: ZNF502
Ensembl: ENSG00000196653
Chromosome: 3
Canonical length: 544 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation by host of viral process and viral release from host cell. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q8TBZ5|ZNF502
     1  MLNMQGAEER DIRRETCPGW VNKNKPALEQ DVCKIDSSGI VVKRFQEDEY QDSTFEEKYA
    61  CEGMKENSPR EIAESCLFQE GGFGRITFIH KEAPPEIISQ GYNFEKSLLL TSSLVTRLRV
   121  STEESLHQWE TSNIQTNDIS DQSKCPTLCT QKKSWKCNEC GKTFTQSSSL TQHQRTHTGE
   181  RPYTCEECGK AFSRSSFLVQ HQRIHTGVKP YGCEQCGKTF RCRSFLTQHQ RIHTGEKPYK
   241  CNECGNSFRN HSHLTEHQRI HTGEKPYKCN RCGKAFNQNT HLIHHQRIHT GEKPYICSEC
   301  GSSFRKHSNL TQHQRIHTGE KPHKCDECGK TFQTKANLSQ HQRIHSGEKP YKCKECGKAF
   361  CQSPSLIKHQ RIHTGEKPYK CKECGKAFTQ STPLTKHQRI HTGERPYKCS ECGKAFIQSI
   421  CLIRHQRSHT GEKPYKCNEC GKGFNQNTCL TQHMRIHTGE KPYKCKECGK AFAHSSSLTE
   481  HHRTHTGEKL YKCSECEKTF RKYAHLSEHY RIHTGEKPYE CIECGKFFRH SSVLFRHQKL
   541  HSGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF502 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 5.3 nTPM
ovary: 5 nTPM
retina: 4.8 nTPM
testis: 4.8 nTPM
prostate: 4.6 nTPM
cervix: 4.4 nTPM

Single-cell type

bergmann glia: 7.9 nCPM
renal connecting tubule cells: 7.8 nCPM
brain inhibitory neurons: 7.5 nCPM
brain excitatory neurons: 6.9 nCPM
oligodendrocyte progenitor cells: 6.8 nCPM
papillary tip epithelial cells: 6.6 nCPM

Immune cell

naive CD4 T-cell: 1.5 nTPM
naive B-cell: 1.2 nTPM
naive CD8 T-cell: 1.2 nTPM
NK-cell: 1.2 nTPM
MAIT T-cell: 1 nTPM
memory CD4 T-cell: 1 nTPM

Brain region

cerebellum: 4.5 nTPM
hypothalamus: 2.7 nTPM
basal ganglia: 2.6 nTPM
midbrain: 2.5 nTPM
cerebral cortex: 2.4 nTPM
medulla oblongata: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF502 as an antibody target. Whether an autoantibody or antibody against ZNF502 could matter depends on whether native ZNF502 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF502 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF502 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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