Seroatlas · Human Serome Atlas

ZNF501

Zinc finger protein 501

Also known as: MGC21738, ZN501_HUMAN, ZNF52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CX3
Gene: ZNF501
Ensembl: ENSG00000186446
Chromosome: 3
Canonical length: 271 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Involved in Golgi organization. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q96CX3|ZNF501
     1  MNSSQISLRM KHGRVNMQKK PSKCSECGKF FTQRSSLTQH QRIHRGEKPY VCSECGSCFR
    61  KQSNLTQHLR IHTGEKPYKC NECEKAFQTK AILVQHLRIH TGEKPYKCNE CGKAFCQSPS
   121  LIKHQRIHTG EKPYKCTECG KAFSQSICLT RHQRSHSGDK PFKCNECGKA FNQSACLMQH
   181  QRIHSGEKPY TCTECGKAFT QNSSLVEHER THTGEKLYKC SECEKTFRKQ AHLSEHYRIH
   241  TGEKPYECVG CGKSFRHSSA LLRHQRLHAG E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF501 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 2 nTPM

Expression across tissuesHPA

Tissue

endometrium: 2 nTPM
cerebellum: 1.9 nTPM
ovary: 1.9 nTPM
colon: 1.8 nTPM
retina: 1.8 nTPM
testis: 1.8 nTPM

Single-cell type

bergmann glia: 8.5 nCPM
oligodendrocyte progenitor cells: 7.3 nCPM
oligodendrocytes: 5.3 nCPM
astrocytes: 4.8 nCPM
microglia: 4 nCPM
brain inhibitory neurons: 3.6 nCPM

Immune cell

naive B-cell: 1 nTPM
eosinophil: 0.9 nTPM
MAIT T-cell: 0.9 nTPM
naive CD4 T-cell: 0.9 nTPM
memory B-cell: 0.8 nTPM
NK-cell: 0.8 nTPM

Brain region

cerebellum: 3.1 nTPM
basal ganglia: 2.6 nTPM
thalamus: 2.5 nTPM
midbrain: 2.4 nTPM
spinal cord: 2.4 nTPM
amygdala: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.28
gnomAD missense Z: -0.53
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF501 as an antibody target. Whether an autoantibody or antibody against ZNF501 could matter depends on whether native ZNF501 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF501 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF501 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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