Seroatlas · Human Serome Atlas

ZNF497

Zinc finger protein 497

Also known as: FLJ44773, ZN497_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNH5
Gene: ZNF497
Ensembl: ENSG00000174586
Chromosome: 19
Canonical length: 498 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>Q6ZNH5|ZNF497
     1  MESPRGWTLQ VAPEEGQVLC NVKTATRGLS EGAVSGGWGA WENSTEVPRE AGDGQRQQAT
    61  LGAADEQGGP GRELGPADGG RDGAGPRSEP ADRALRPSPL PEEPGCRCGE CGKAFSQGSY
   121  LLQHRRVHTG EKPYTCPECG KAFAWSSNLS QHQRIHSGEK PYACRECGKA FRAHSQLIHH
   181  QETHSGLKPF RCPDCGKSFG RSTTLVQHRR THTGEKPYEC PECGKAFSWN SNFLEHRRVH
   241  TGARPHACRD CGKAFSQSSN LAEHLKIHAG ARPHACPDCG KAFVRVAGLR QHRRTHSSEK
   301  PFPCAECGKA FRESSQLLQH QRTHTGERPF ECAECGQAFV MGSYLAEHRR VHTGEKPHAC
   361  AQCGKAFSQR SNLLSHRRTH SGAKPFACAD CGKAFRGSSG LAHHRLSHTG ERPFACAECG
   421  KAFRGSSELR QHQRLHSGER PFVCAHCSKA FVRKSELLSH RRTHTGERPY ACGECGKPFS
   481  HRCNLNEHQK RHGGRAAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF497 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 4.8 nTPM
fallopian tube: 4.8 nTPM
pituitary gland: 3.9 nTPM
thyroid gland: 3.4 nTPM
basal ganglia: 3.2 nTPM
cerebral cortex: 3.2 nTPM

Single-cell type

ependymal cells: 18 nCPM
choroid plexus epithelial cells: 7.6 nCPM
podocytes: 7.5 nCPM
proximal tubule cells: 7.1 nCPM
loop of henle epithelial cells: 6.6 nCPM
renal collecting duct principal cells: 6.3 nCPM

Immune cell

plasmacytoid DC: 1.7 nTPM
naive CD8 T-cell: 1.6 nTPM
naive B-cell: 1.5 nTPM
basophil: 1.3 nTPM
memory B-cell: 1.3 nTPM
T-reg: 1.2 nTPM

Brain region

cerebellum: 25 nTPM
choroid plexus: 20 nTPM
white matter: 19 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 17 nTPM
hippocampal formation: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.22
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF497 as an antibody target. Whether an autoantibody or antibody against ZNF497 could matter depends on whether native ZNF497 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF497 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF497 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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