ZNF493
Zinc finger protein 493
Also known as: FLJ36504, ZN493_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZR52
- Gene
- ZNF493
- Ensembl
- ENSG00000196268
- Chromosome
- 19
- Canonical length
- 646 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
646 residues, UniProt reviewed canonical sequence.
>Q6ZR52|ZNF493
1 MNECNVHKEG YNELNQYLTT TQSKIFQCDK YVKVFHKLLN SNRHNTKHTG KKPFKCKKCG
61 KSFCMLLHLC QHKRIHIREN SYRCEECGKA FIWFSTLTRH RRVHTGEKSY KYECGKSFNQ
121 DSNLTTHKRI HTGQKPYKCE ECGTSFYQFS YLTRHKLIHT REKPYKCEQY GKTFNQSSTL
181 TGHKIIHNGE KPYKCEECGK AFSIFSTPTK HKIIHTEEKS HRCEEYCKAY KESSHLTTHK
241 RIHTGEKPYK CEECGKAFSI FSTLTKHKII HTEEKSHRCE ECGKAYKESS HLTTHKRIHT
301 GEKPYKCEEC GKTFSVFSIL TKHKIIHTEE KPYKCEECGK AFKRSSTLTK HRIIHTEEKP
361 YKCEECGKAF NQSSTLSIHK IIHTGEKPYK CEECGKAFKR SSTLTIHKMI HTGEKPYKCE
421 ECGKAFNRSS HLTTHKRIHT GHKPYKCKEC GKSFSVFSTL TKHKIIHTDK KPYKCEECGK
481 AFNRSSILSI HKKIHTGEKP YKCEECGKAF KRSSHLAGHK QIHSVQKPYK CEECGKAFSI
541 FSTLTKHKII HTEEKPYKCE KCGKTFYRFS NLNTHKIIHT GEKPCKCEEC GKAFNHSSNL
601 IKHKLIHTGD KPYKCEACGK AFRRSSHLSR HKIIHIGIHT EETVQKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF493 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 29 nTPM
- thyroid gland: 19 nTPM
- retina: 17 nTPM
- ovary: 16 nTPM
- thymus: 13 nTPM
- lymph node: 11 nTPM
Single-cell type
- cardiomyocytes: 93 nCPM
- adrenal medulla cells: 75 nCPM
- neutrophils: 65 nCPM
- sertoli cells: 58 nCPM
- myonuclei: 56 nCPM
- choroid plexus epithelial cells: 54 nCPM
Immune cell
- neutrophil: 34 nTPM
- memory B-cell: 16 nTPM
- naive B-cell: 16 nTPM
- naive CD4 T-cell: 15 nTPM
- naive CD8 T-cell: 14 nTPM
- NK-cell: 14 nTPM
Brain region
- cerebellum: 109 nTPM
- white matter: 64 nTPM
- basal ganglia: 61 nTPM
- pons: 61 nTPM
- cerebral cortex: 60 nTPM
- thalamus: 56 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.08
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF493 as an antibody target. Whether an autoantibody or antibody against ZNF493 could matter depends on whether native ZNF493 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF493 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF493 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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