Seroatlas · Human Serome Atlas

ZNF492

Zinc finger protein 492

Also known as: KIAA1473, ZN492_HUMAN, ZNF115

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P255
Gene: ZNF492
Ensembl: ENSG00000229676
Chromosome: 19
Canonical length: 531 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

531 residues, UniProt reviewed canonical sequence.

>Q9P255|ZNF492
     1  MLENYRNLVF VGIAASKPDL ITCLEQGKEP WNVKRHEMVA EPPVVCSYFA RDLWPKQGKK
    61  NYFQKVILRR YKKCGCENLQ LRKYCKSMDE CKVHKECYNG LNQCLTTTQN KIFQCDKYVK
   121  VFHKFSNSNR HTIRHTGKKS FKCKECEKSF CMLSHLAQHK RIHSGEKPYK CKECGKAYNE
   181  TSNLSTHKRI HTGKKPYKCE ECGKAFNRLS HLTTHKIIHT GKKPYKCEEC GKAFNQSANL
   241  TTHKRIHTGE KPYKCEECGR AFSQSSTLTA HKIIHAGEKP YKCEECGKAF SQSSTLTTHK
   301  IIHTGEKFYK CEECGKAFSQ LSHLTTHKRI HSGEKPYKCE ECGKAFKQSS TLTTHKRIHA
   361  GEKFYKCEVC SKAFSRFSHL TTHKRIHTGE KPYKCEECGK AFNLSSQLTT HKIIHTGEKP
   421  YKCEECGKAF NQSSTLSKHK VIHTGEKPYK YEECGKAFNQ SSHLTTHKMI HTGEKPYKCE
   481  ECGKAFNNSS ILNRHKMIHT GEKLYKPESC NNACDNIAKI SKYKRNCAGE K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF492 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 2.4 nTPM
testis: 1.8 nTPM
breast: 0.7 nTPM
thymus: 0.6 nTPM
ovary: 0.5 nTPM
adipose tissue: 0.3 nTPM

Single-cell type

erythrocyte progenitors: 26 nCPM
differentiating spermatogonia: 19 nCPM
undifferentiated spermatogonia: 13 nCPM
early primary spermatocytes: 13 nCPM
granulosa cells: 9.7 nCPM
megakaryocyte progenitors: 8 nCPM

Immune cell

naive B-cell: 0.5 nTPM
basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebellum: 3.1 nTPM
cerebral cortex: 2.4 nTPM
white matter: 2 nTPM
amygdala: 1.9 nTPM
choroid plexus: 1.8 nTPM
hippocampal formation: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0.19
gnomAD missense Z: -0.79
DepMap mean gene effect: -0.84
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF492 as an antibody target. Whether an autoantibody or antibody against ZNF492 could matter depends on whether native ZNF492 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF492 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF492 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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