ZNF491
Zinc finger protein 491
Also known as: FLJ34791, ZN491_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N8L2
- Gene
- ZNF491
- Ensembl
- ENSG00000177599
- Chromosome
- 19
- Canonical length
- 437 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
437 residues, UniProt reviewed canonical sequence.
>Q8N8L2|ZNF491
1 MGERLFESAE GSQCGETFTQ VPEDMLNKKT LPGVKSCESG TCGEIFMGYS SFNRNIRTDT
61 GHQPHKCQKF LEKPYKHKQR RKALSHSHCF RTHERPHTRE KPFDCKECEK SFISPASIRR
121 YMVTHSGDGP YKCKFCGKAL DCLSLYLTHE RTHTGEKRYE CKQCGKAFSW HSSVRIHERT
181 HTGEKPYECK ECGKSFNFSS SFRRHERTHT GEKPYKCKEC GKAFNCPSSF HRHERTHTGE
241 KPYECKLYGK ALSRLISFRR HMRMHTGERP HKCKICGKAF YSPSSFQRHE RSHTGEKPYK
301 CKQCGKAFTC STSFQYHERT HTGEKPDGCK QCGKAFRSAK YIRIHGRTHT GEKPYECKQC
361 GKAFHCVSSF HRHERTHAGE KPYECKHCGK AFTCSIYIRI HERIHTGEKP YQCKECGKAF
421 IRSSYCRKHE RTHTINILocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF491 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 8.9 nTPM
Expression across tissuesHPA
Tissue
- retina: 8.9 nTPM
- cerebellum: 2.7 nTPM
- thymus: 2.4 nTPM
- choroid plexus: 2.2 nTPM
- pituitary gland: 2.2 nTPM
- ovary: 2 nTPM
Single-cell type
- early spermatids: 85 nCPM
- late spermatids: 54 nCPM
- rod photoreceptor cells: 33 nCPM
- choroid plexus epithelial cells: 29 nCPM
- cone photoreceptor cells: 23 nCPM
- myonuclei: 16 nCPM
Immune cell
- memory B-cell: 0.7 nTPM
- basophil: 0.6 nTPM
- naive CD4 T-cell: 0.5 nTPM
- neutrophil: 0.4 nTPM
- NK-cell: 0.3 nTPM
- plasmacytoid DC: 0.3 nTPM
Brain region
- cerebellum: 11 nTPM
- choroid plexus: 7.8 nTPM
- cerebral cortex: 6.4 nTPM
- white matter: 6.3 nTPM
- basal ganglia: 6.2 nTPM
- hippocampal formation: 5.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.39
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF491 as an antibody target. Whether an autoantibody or antibody against ZNF491 could matter depends on whether native ZNF491 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF491 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF491 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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