ZNF487
Zinc finger protein 487
Also known as: ZN487_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- B1APH4
- Gene
- ZNF487
- Canonical length
- 207 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for ZNF487 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
207 residues, UniProt reviewed canonical sequence.
>B1APH4|ZNF487
1 MLENYSLLLS VGYCITKPEV VCKLEHGQVL WILEEESPSQ SHLDCCIDDD LMEKRQENQD
61 QHLQKVDFVN NKTLTMDRNG VLGKTFSLDT NPILSRKIRG NCDSSGMNLN NISELIISNR
121 SSFVRNPAEC NVRGKFLLCM KRENPYARGK PLEYDGNGKA VSQNEDLFRH QYIQTLKQCF
181 EYNQCGKAFH EEAACSTHKR VCSWETLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF487 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- testis: 26 nTPM
- choroid plexus: 10 nTPM
- retina: 8.3 nTPM
- fallopian tube: 5.7 nTPM
- bone marrow: 4.1 nTPM
- ovary: 3.7 nTPM
Single-cell type
- late spermatids: 441 nCPM
- early spermatids: 236 nCPM
- respiratory ciliated cells: 146 nCPM
- ependymal cells: 123 nCPM
- late primary spermatocytes: 101 nCPM
- endometrial ciliated cells: 97 nCPM
Immune cell
- neutrophil: 11 nTPM
- eosinophil: 4.5 nTPM
- myeloid DC: 3.9 nTPM
- gdT-cell: 3.3 nTPM
- classical monocyte: 3 nTPM
- memory CD8 T-cell: 2.9 nTPM
Brain region
- medulla oblongata: 24 nTPM
- cerebral cortex: 20 nTPM
- midbrain: 20 nTPM
- pons: 18 nTPM
- spinal cord: 17 nTPM
- choroid plexus: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 1.24
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF487 as an antibody target. Whether an autoantibody or antibody against ZNF487 could matter depends on whether native ZNF487 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF487 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF487 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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