Seroatlas · Human Serome Atlas

ZNF486

Zinc finger protein 486

Also known as: KRBO2, MGC2396, ZN486_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96H40
Gene: ZNF486
Ensembl: ENSG00000256229
Chromosome: 19
Canonical length: 463 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>Q96H40|ZNF486
     1  MPGPLRSLEM ESLQFRDVAV EFSLEEWHCL DTAQQNLYRD VMLENYRHLV FLGIIVSKPD
    61  LITCLEQGIK PLTMKRHEMI AKPPVVCSHF AQDLWPEQSI KDSYQKVILR KFEKCGHGNL
   121  HFKKGCESVD ECKLHKRGYN GLNQCLTTTQ SKIFQCGKYV KVFHQFSNSK RHKRRHTEKK
   181  PLKYIEGDKA FNQSSTHTTH KKIDTGEKPY KCEECGKAFN RSSHLTTHKI THTREKPYKC
   241  EECGKVFKYF SSFTTHKKIH SGEKPYICEE CGKAFMYPYT LTTHKIIHTG EQPYKCKECD
   301  KAFNHPATLS SHKKIHTGEK PYTCDKCGKA FISSSILSKH EKIHTGEKPY KCEECGKAFT
   361  RSSHLTMHKI IHTGEKPYKC EECGKAFTWS AGLHKHRRTH TGEKPYKCEE CGKAYTTSSN
   421  LTEHKTTHTG EKPYKCKECG KAFNWSSDLN KHKRIHIGQK PRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF486 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 32 nTPM
urinary bladder: 11 nTPM
breast: 7.9 nTPM
cervix: 7.9 nTPM
ovary: 7.7 nTPM
placenta: 7.5 nTPM

Single-cell type

papillary tip epithelial cells: 102 nCPM
prostatic hillock cells: 53 nCPM
extravillous trophoblasts: 51 nCPM
renal connecting tubule cells: 50 nCPM
urothelial cells: 43 nCPM
renal collecting duct principal cells: 40 nCPM

Immune cell

neutrophil: 9.6 nTPM
basophil: 2.5 nTPM
naive B-cell: 2.2 nTPM
naive CD8 T-cell: 2.2 nTPM
memory B-cell: 1.6 nTPM
T-reg: 1.6 nTPM

Brain region

cerebellum: 12 nTPM
white matter: 11 nTPM
medulla oblongata: 10 nTPM
basal ganglia: 9.1 nTPM
midbrain: 9 nTPM
pons: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -2.58
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF486 as an antibody target. Whether an autoantibody or antibody against ZNF486 could matter depends on whether native ZNF486 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF486 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF486 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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