ZNF485
Zinc finger protein 485
Also known as: ZN485_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NCK3
- Gene
- ZNF485
- Ensembl
- ENSG00000198298
- Chromosome
- 10
- Canonical length
- 441 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
441 residues, UniProt reviewed canonical sequence.
>Q8NCK3|ZNF485
1 MAPRAQIQGP LTFGDVAVAF TRIEWRHLDA AQRALYRDVM LENYGNLVSV GLLSSKPKLI
61 TQLEQGAEPW TEVREAPSGT HAVEDYWFET KMSALKQSTS EASVLGERTK SVMMEKGLDW
121 EGRSSTEKNY KCKECGKVFK YNSSFISHQR NHTSEKPHKC KECGIAFMNS SSLLNHHKVH
181 AGKQPYRCIE CGKFLKKHST FINHQRIHSR EKPHKCIECG KTFRKNSILL SHQRIHTGQK
241 PYKCNDCGKA FAQNAALTRH ERIHSGEKPF KCNKCGRAFR DNSTVLEHQK IHTGEKPYQC
301 NECGKAFRKS STLISHQRMH TGEKPYHCSK CGKSFRYSSS FAGHQKTHSG NKPYQCRDCG
361 KAFTKSSTLT GHQRIHTGEK PYHCKKCGKA FRHSSGLVEH QRLHTGEKPY KCNECGKAFP
421 RSSALKQHKK IHNKERAMKC SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF485 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 4 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 4 nTPM
- testis: 3.6 nTPM
- breast: 3.1 nTPM
- skin: 3.1 nTPM
- lymph node: 3 nTPM
- skeletal muscle: 3 nTPM
Single-cell type
- late primary spermatocytes: 33 nCPM
- hepatic stellate cells: 13 nCPM
- oocytes: 9.2 nCPM
- differentiating spermatogonia: 8.5 nCPM
- myosatellite cells: 8.2 nCPM
- early spermatids: 6.9 nCPM
Immune cell
- NK-cell: 14 nTPM
- naive CD4 T-cell: 9.2 nTPM
- MAIT T-cell: 6.7 nTPM
- memory B-cell: 6 nTPM
- naive CD8 T-cell: 5.7 nTPM
- memory CD4 T-cell: 5.5 nTPM
Brain region
- white matter: 6 nTPM
- hypothalamus: 5.3 nTPM
- pons: 5.2 nTPM
- basal ganglia: 4.9 nTPM
- midbrain: 4.9 nTPM
- medulla oblongata: 4.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.03
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.72
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF485 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF485 as an antibody target. Whether an autoantibody or antibody against ZNF485 could matter depends on whether native ZNF485 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF485 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF485 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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