Seroatlas · Human Serome Atlas

ZNF484

Zinc finger protein 484

Also known as: BA526D8.4, FLJ33884, ZN484_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JVG2
Gene: ZNF484
Ensembl: ENSG00000127081
Chromosome: 9
Canonical length: 852 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

852 residues, UniProt reviewed canonical sequence.

>Q5JVG2|ZNF484
     1  MTKSLESVSF KDVTVDFSRD EWQQLDLAQK SLYREVMLEN YFNLISVGCQ VPKPEVIFSL
    61  EQEEPCMLDG EIPSQSRPDG DIGFGPLQQR MSEEVSFQSE ININLFTRDD PYSILEELWK
   121  DDEHTRKCGE NQNKPLSRVV FINKKTLAND SIFEYKDIGE IVHVNTHLVS SRKRPHNCNS
   181  CGKNLEPIIT LYNRNNATEN SDKTIGDGDI FTHLNSHTEV TACECNQCGK PLHHKQALIQ
   241  QQKIHTRESL YLFSDYVNVF SPKSHAFAHE SICAEEKQHE CHECEAVFTQ KSQLDGSQRV
   301  YAGICTEYEK DFSLKSNRQK TPYEGNYYKC SDYGRAFIQK SDLFRCQRIH SGEKPYEYSE
   361  CEKNLPQNSN LNIHKKIHTG GKHFECTECG KAFTRKSTLS MHQKIHTGEK PYVCTECGKA
   421  FIRKSHFITH ERIHTGEKPY ECSDCGKSFI KKSQLHVHQR IHTGENPFIC SECGKVFTHK
   481  TNLIIHQKIH TGERPYICTV CGKAFTDRSN LIKHQKIHTG EKPYKCSDCG KSFTWKSRLR
   541  IHQKCHTGER HYECSECGKA FIQKSTLSMH QRIHRGEKPY VCTECGKAFF HKSHFITHER
   601  IHTGEKPYEC SICGKSFTKK SQLHVHQQIH TGEKPYRCAE CGKAFTDRSN LFTHQKIHTG
   661  EKPYKCSDCG KAFTRKSGLH IHQQSHTGER HYECSECGKA FARKSTLIMH QRIHTGEKPY
   721  ICNECGKSFI QKSHLNRHRR IHTGEKPYEC SDCGKSFIKK SQLHEHHRIH TGEKPYICAE
   781  CGKAFTIRSN LIKHQKIHTK QKPYKCSDLG KALNWKPQLS MPQKSDNGEV ECSMPQLWCG
   841  DSEGDQGQLS SI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF484 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

retina: 4.9 nTPM
cerebellum: 4.1 nTPM
bone marrow: 3.9 nTPM
parathyroid gland: 3.4 nTPM
ovary: 2.9 nTPM
thyroid gland: 2.9 nTPM

Single-cell type

tuft cells: 35 nCPM
nk-cells: 28 nCPM
lactotrophs: 28 nCPM
retinal ganglion cells: 27 nCPM
other brain neurons: 26 nCPM
corticotrophs: 25 nCPM

Immune cell

naive CD4 T-cell: 3.4 nTPM
naive CD8 T-cell: 3.2 nTPM
MAIT T-cell: 3.1 nTPM
eosinophil: 2.8 nTPM
memory CD4 T-cell: 2.6 nTPM
naive B-cell: 2.6 nTPM

Brain region

cerebellum: 32 nTPM
white matter: 19 nTPM
hypothalamus: 19 nTPM
cerebral cortex: 18 nTPM
pons: 18 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 1.51
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF484 as an antibody target. Whether an autoantibody or antibody against ZNF484 could matter depends on whether native ZNF484 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF484 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF484 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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