Seroatlas · Human Serome Atlas

ZNF480

Zinc finger protein 480

Also known as: MGC32104, ZN480_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WV37
Gene
ZNF480
Ensembl
ENSG00000198464
Chromosome
19
Canonical length
535 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>Q8WV37|ZNF480
     1  MLCDEKAQKR RKRKAKESGM ALPQGHLTFR DVAIEFSQAE WKCLDPAQRA LYKDVMLENY
    61  RNLVSLGISL PDLNINSMLE QRREPWSGES EVKIAKNSDG RECIKGVNTG SSYALGSNAE
   121  DKPIKKQLGV SFHLHLSELE LFPDERVING CNQVENFINH SSSVSCLQEM SSSVKTPIFN
   181  RNDFDDSSFL PQEQKVHLRE KPYECNEHSK VFRVSSSLTK HQVIHTVEKP YKCNSCGKVF
   241  SRNSHLAEHC RIHTGEKPYK CNVCGKVFSY NSNFARHQRI HTREKPYECN ECGKVFSNNS
   301  YLARHQRIHA EEKPYKCNEC GKGFSHKSSL ANHWRIYTGE KPYKCDECGK AFYRIALLVR
   361  HQKIHTGEKP YKCNECGKVF IQNSHLAQHW RIHTGEKPYK CNECGKVFNQ LSNLARHRRI
   421  HTGEKPYKCN ECGKAFSEYS GLSAHLVIHT GEKPYKCSEC GKAFRHKLSL TNHQRIHTGE
   481  RPYKCNECGK VFNRIAHLAR HRKIHTGEKP YKCNECGKAF SRISYLAQHW TIHMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF480 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 15 nTPM
  • thymus: 14 nTPM
  • tongue: 14 nTPM
  • lymph node: 12 nTPM
  • choroid plexus: 11 nTPM
  • heart muscle: 10 nTPM

Single-cell type

  • cone photoreceptor cells: 46 nCPM
  • rod photoreceptor cells: 44 nCPM
  • b-cells: 36 nCPM
  • conjunctival goblet cells: 36 nCPM
  • myonuclei: 36 nCPM
  • respiratory ionocytes: 36 nCPM

Immune cell

  • memory B-cell: 20 nTPM
  • plasmacytoid DC: 19 nTPM
  • naive B-cell: 19 nTPM
  • NK-cell: 18 nTPM
  • naive CD8 T-cell: 16 nTPM
  • T-reg: 16 nTPM

Brain region

  • white matter: 28 nTPM
  • cerebellum: 27 nTPM
  • cerebral cortex: 25 nTPM
  • medulla oblongata: 25 nTPM
  • pons: 24 nTPM
  • hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0.04
gnomAD missense Z
0.35
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF480 as an antibody target. Whether an autoantibody or antibody against ZNF480 could matter depends on whether native ZNF480 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF480 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF480 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF480. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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