Seroatlas · Human Serome Atlas

ZNF479

Zinc finger protein 479

Also known as: KR19, ZN479_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JC4
Gene: ZNF479
Ensembl: ENSG00000185177
Chromosome: 7
Canonical length: 524 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>Q96JC4|ZNF479
     1  MAKRPGPPGS REMGLLTFRD IAIEFSLEEW QCLDCAQRNL YRDVMLENYR NLVSLGIAVS
    61  KPDLITCLEQ NKESQNIKRN EMVAKHPVTR SHFTQDLQPE QGIKDSLQKV IPRTYGKCGH
   121  EKLQFKKCCK SVGEYEVHKG GYSEVNQCLS TTQNKIFQTH KYVKVFGKFS NSNRDKTRYT
   181  GNKHFKCNKY GKSFCMLSHL NQHQVIHTRE KSYKCKECGK SFNCSSNHTT HKIIHTGEKP
   241  YRCEECGKAF SWSANLTRHK RTHTGEKPYT CEECGQAFRR SSALTNHKRI HTGERPYKCE
   301  ECGKAFSVSS TLTDHKRIHT GEKPCRCEEC GKAFSWSSNL TRHKRIHTRE KPYACEECGQ
   361  AFSLSSNLMR HRRIHTGEKP YTCEECGQDF RRSSALTIHK RIHTGERPYK CEECGKVFSL
   421  SSTLTDHKRI HTGERPYKCE ECGKAFSLSS TLTDHKRIHT GERPYTCEEC GKAFNCSSTL
   481  MQHKRIHTGE KPYKCEECEQ AFKWHSSLAK HKIIHTGEKP YKCE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF479 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

testis: 2.6 nTPM
bone marrow: 0.1 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

early spermatids: 115 nCPM
late primary spermatocytes: 37 nCPM
late spermatids: 35 nCPM
tuft cells: 12 nCPM
differentiating spermatogonia: 9 nCPM
undifferentiated spermatogonia: 4.2 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 2.2 nTPM
cerebral cortex: 2.1 nTPM
basal ganglia: 2 nTPM
white matter: 2 nTPM
hippocampal formation: 1.9 nTPM
amygdala: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -1.17
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF479 as an antibody target. Whether an autoantibody or antibody against ZNF479 could matter depends on whether native ZNF479 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF479 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF479 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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