Seroatlas · Human Serome Atlas

ZNF471

Zinc finger protein 471

Also known as: KIAA1396, Z1971, Zfp78, ZN471_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BX82
Gene
ZNF471
Ensembl
ENSG00000196263
Chromosome
19
Canonical length
626 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q9BX82|ZNF471
     1  MNVEVVKVMP QDLVTFKDVA IDFSQEEWQW MNPAQKRLYR SMMLENYQSL VSLGLCISKP
    61  YVISLLEQGR EPWEMTSEMT RSPFSDWESI YVTQELPLKQ FMYDDACMEG ITSYGLECST
   121  FEENWKWEDL FEKQMGSHEM FSKKEIITHK ETITKETEFK YTKFGKCIHL ENIEESIYNH
   181  TSDKKSFSKN SMVIKHKKVY VGKKLFKCNE CDKTFTHSSS LTVHFRIHTG EKPYACEECG
   241  KAFKQRQHLA QHHRTHTGEK LFECKECRKA FKQSEHLIQH QRIHTGEKPY KCKECRKAFR
   301  QPAHLAQHQR IHTGEKPYEC KECGKAFSDG SSFARHQRCH TGKRPYECIE CGKAFRYNTS
   361  FIRHWRSYHT GEKPFNCIDC GKAFSVHIGL ILHRRIHTGE KPYKCGVCGK TFSSGSSRTV
   421  HQRIHTGEKP YECDICGKDF SHHASLTQHQ RVHSGEKPYE CKECGKAFRQ NVHLVSHLRI
   481  HTGEKPYECK ECGKAFRISS QLATHQRIHT GEKPYECIEC GNAFKQRSHL AQHQKTHTGE
   541  KPYECNECGK AFSQTSNLTQ HQRIHTGEKP YKCTECGKAF SDSSSCAQHQ RLHTGQRPYQ
   601  CFECGKAFRR KLSLICHQRS HTGEEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF471 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • retina: 26 nTPM
  • ovary: 16 nTPM
  • epididymis: 15 nTPM
  • endometrium: 12 nTPM
  • cerebellum: 11 nTPM
  • fallopian tube: 10 nTPM

Single-cell type

  • oligodendrocytes: 44 nCPM
  • myonuclei: 35 nCPM
  • sertoli cells: 35 nCPM
  • fibro-adipogenic progenitors: 32 nCPM
  • adipocytes: 31 nCPM
  • podocytes: 31 nCPM

Immune cell

  • neutrophil: 1.3 nTPM
  • basophil: 1.2 nTPM
  • naive B-cell: 0.8 nTPM
  • NK-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.6 nTPM
  • gdT-cell: 0.5 nTPM

Brain region

  • white matter: 72 nTPM
  • hypothalamus: 58 nTPM
  • basal ganglia: 56 nTPM
  • medulla oblongata: 55 nTPM
  • thalamus: 54 nTPM
  • cerebral cortex: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.99
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF471 as an antibody target. Whether an autoantibody or antibody against ZNF471 could matter depends on whether native ZNF471 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF471 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF471 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF471. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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