Seroatlas · Human Serome Atlas

ZNF470

Zinc finger protein 470

Also known as: CZF-1, FLJ26175, ZN470_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ECI4
Gene
ZNF470
Ensembl
ENSG00000197016
Chromosome
19
Canonical length
717 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

717 residues, UniProt reviewed canonical sequence.

>Q6ECI4|ZNF470
     1  MKSQEEVEVA GIKLCKAMSL GSVTFTDVAI DFSQDEWEWL NLAQRSLYKK VMLENYRNLV
    61  SVGLCISKPD VISLLEQEKD PWVIKGGMNR GLCPDLECVW VTKSLSLNQD IYEEKLPPAI
   121  IMERLKSYDL ECSTLGKNWK CEDLFERELV NQKTHFRQET ITHIDTLIEK RDHSNKSGTV
   181  FHLNTLSYIK QIFPMEERIF NFHTDKKSLK THSVVKKHKQ DRGEKKLLKC NDCEKIFSKI
   241  STLTLHQRIH TGEKPYECIE CGKAFSQSAH LAQHQRIHTG EKPFECTECG KAFSQNAHLV
   301  QHQRVHTGEK PYQCKQCNKA FSQLAHLAQH QRVHTGEKPY ECIECGKAFS DCSSLAHHRR
   361  IHTGKRPYEC IDCGKAFRQN ASLIRHRRYY HTGEKPFDCI DCGKAFTDHI GLIQHKRTHT
   421  GERPYKCNVC GKAFSHGSSL TVHQRIHTGE KPYECNICEK AFSHRGSLTL HQRVHTGEKP
   481  YECKECGKAF RQSTHLAHHQ RIHTGEKPYE CKECSKTFSQ NAHLAQHQKI HTGEKPYECK
   541  ECGKAFSQIA HLVQHQRVHT GEKPYECIEC GKAFSDGSYL VQHQRLHSGK RPYECLECGK
   601  AFRQRASLIC HQRCHTGEKP YECNVCGKAF SHRKSLTLHQ RIHTGEKPYE CKECSKAFSQ
   661  VAHLTLHKRI HTGERPYECK ECGKAFRQSV HLAHHQRIHT GESSVILSSA LPYHQVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF470 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • retina: 11 nTPM
  • hippocampal formation: 9.9 nTPM
  • spinal cord: 9.8 nTPM
  • cerebellum: 9.5 nTPM
  • hypothalamus: 9.4 nTPM
  • midbrain: 9.4 nTPM

Single-cell type

  • early primary spermatocytes: 16 nCPM
  • differentiating spermatogonia: 15 nCPM
  • oligodendrocytes: 13 nCPM
  • retinal pigment epithelial cells: 13 nCPM
  • rod photoreceptor cells: 13 nCPM
  • undifferentiated spermatogonia: 12 nCPM

Immune cell

  • MAIT T-cell: 1.3 nTPM
  • eosinophil: 0.9 nTPM
  • naive B-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • memory B-cell: 0.7 nTPM

Brain region

  • cerebellum: 14 nTPM
  • medulla oblongata: 14 nTPM
  • midbrain: 13 nTPM
  • thalamus: 13 nTPM
  • hypothalamus: 13 nTPM
  • hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.55
gnomAD pLI
0
gnomAD missense Z
-0.98
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF470 as an antibody target. Whether an autoantibody or antibody against ZNF470 could matter depends on whether native ZNF470 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF470 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF470 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF470. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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