Seroatlas · Human Serome Atlas

ZNF468

Zinc finger protein 468

Also known as: ZN468_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VIY5
Gene: ZNF468
Ensembl: ENSG00000204604
Chromosome: 19
Canonical length: 522 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q5VIY5|ZNF468
     1  MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMLKTLSS
    61  TGQGNTEVIH TGTLHRQASH HIGEFCFHEI EKDIHGFEFQ WKEDETNGHA APMTEIKELA
   121  GSTGQHDQRH AGNKRIKDQL GSSFHLHLPE PHIFQSEGKI GNQVEKSINN ASSVSTSQRI
   181  CCRPKTHISN KYGNNSLHSS LLTQKWEVHM REKSFECIQS FKSFNCSSLL KKHQIIHLEE
   241  KQCKCDVCGK VFNQKRYLAC HRRCHTGEKP YKCNECGKTF GHNSSLFIHK ALHTGEKPYE
   301  CEECDKVFSR KSHLERHKRI HTGEKPYKCK VCDEAFAYNS YLAKHTILHT GEKPYTCNEC
   361  GKVFNRLSTL ARHHRLHTGE KPYKCEECDK VFSRKSHLER HRRIHSGEKP YKCEECCKVF
   421  SRKSNLERHR RIHTGEKPYK CKVCDKAFQR DSHLAQHQRV HTGEKPYKCN ECGKTFGQTS
   481  SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL VYHHRLHSGE KP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF468 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 11 nTPM
placenta: 8.8 nTPM
bone marrow: 6.9 nTPM
prostate: 6.8 nTPM
rectum: 6.8 nTPM
stomach: 6.7 nTPM

Single-cell type

epididymal clear cells: 2 nCPM
conjunctival goblet cells: 1.9 nCPM
parietal cells: 1.8 nCPM
hematopoietic stem cells: 1 nCPM
endometrial glandular cells: 0.7 nCPM
endometrial luminal cells: 0.7 nCPM

Immune cell

NK-cell: 17 nTPM
eosinophil: 11 nTPM
MAIT T-cell: 11 nTPM
gdT-cell: 10 nTPM
intermediate monocyte: 9 nTPM
T-reg: 8.9 nTPM

Brain region

cerebellum: 9.8 nTPM
choroid plexus: 7 nTPM
white matter: 7 nTPM
amygdala: 6.6 nTPM
pons: 6.4 nTPM
cerebral cortex: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -1.37
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF468 as an antibody target. Whether an autoantibody or antibody against ZNF468 could matter depends on whether native ZNF468 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF468 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF468 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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