Seroatlas · Human Serome Atlas

ZNF45

Zinc finger protein 45

Also known as: ZNF13, ZNF45_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q02386
Gene: ZNF45
Ensembl: ENSG00000124459
Chromosome: 19
Canonical length: 682 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

682 residues, UniProt reviewed canonical sequence.

>Q02386|ZNF45
     1  MTKSKEAVTF KDVAVVFSEE ELQLLDLAQR KLYRDVMLEN FRNVVSVGHQ STPDGLPQLE
    61  REEKLWMMKM ATQRDNSSGA KNLKEMETLQ EVGLRYLPHE ELFCSQIWQQ ITRELIKYQD
   121  SVVNIQRTGC QLEKRDDLHY KDEGFSNQSS HLQVHRVHTG EKPYKGEHCV KSFSWSSHLQ
   181  INQRAHAGEK PYKCEKCDNA FRRFSSLQAH QRVHSRAKSY TNDASYRSFS QRSHLPHHQR
   241  VPTGENPYKY EECGRNVGKS SHCQAPLIVH TGEKPYKCEE CGVGFSQRSY LQVHLKVHTG
   301  KKPYKCEECG KSFSWRSRLQ AHERIHTGEK PYKCNACGKS FSYSSHLNIH CRIHTGEKPY
   361  KCEECGKGFS VGSHLQAHQI SHTGEKPYKC EECGKGFCRA SNLLDHQRGH TGEKPYQCDA
   421  CGKGFSRSSD FNIHFRVHTG EKPYKCEECG KGFSQASNLL AHQRGHTGEK PYKCGTCGKG
   481  FSRSSDLNVH CRIHTGEKPY KCERCGKAFS QFSSLQVHQR VHTGEKPYQC AECGKGFSVG
   541  SQLQAHQRCH TGEKPYQCEE CGKGFCRASN FLAHRGVHTG EKPYRCDVCG KRFRQRSYLQ
   601  AHQRVHTGER PYKCEECGKV FSWSSYLQAH QRVHTGEKPY KCEECGKGFS WSSSLIIHQR
   661  VHADDEGDKD FPSSEDSHRK TR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

thymus: 10 nTPM
parathyroid gland: 9.1 nTPM
ovary: 8 nTPM
retina: 7.9 nTPM
thyroid gland: 7 nTPM
lymph node: 6.8 nTPM

Single-cell type

cardiomyocytes: 40 nCPM
myonuclei: 22 nCPM
adrenal cortex cells: 22 nCPM
megakaryocytes: 19 nCPM
fibro-adipogenic progenitors: 17 nCPM
retinal horizontal cells: 16 nCPM

Immune cell

MAIT T-cell: 8.4 nTPM
naive CD4 T-cell: 7.5 nTPM
NK-cell: 6.4 nTPM
T-reg: 6.2 nTPM
memory CD8 T-cell: 6 nTPM
memory B-cell: 5.9 nTPM

Brain region

cerebellum: 16 nTPM
hypothalamus: 13 nTPM
white matter: 12 nTPM
choroid plexus: 11 nTPM
medulla oblongata: 11 nTPM
basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF45 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF45 as an antibody target. Whether an autoantibody or antibody against ZNF45 could matter depends on whether native ZNF45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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