Seroatlas · Human Serome Atlas

ZNF443

Zinc finger protein 443

Also known as: ZK1, ZN443_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2A4
Gene: ZNF443
Ensembl: ENSG00000180855
Chromosome: 19
Canonical length: 671 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Centriolar satellite

OverviewNCBI Gene

Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these proteins, see ZNF91 (MIM 603971).[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

671 residues, UniProt reviewed canonical sequence.

>Q9Y2A4|ZNF443
     1  MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVVMKWKDQ NIEDQYRYPR
    61  KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV GPCESSMRGE KVMGHSSLNC
   121  YIRVGAGHKP HEYHECGEKP DTHKQRGKAF SYHNSFQTHE RLHTGKKPYD CKECGKSFSS
   181  LGNLQRHMAV QRGDGPYKCK LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY
   241  LRHERTHTGE KPYECKQCSK AFPFYSSYLR HERTHTGEKP YKCKQCSKAF PDSSSCLIHE
   301  RTHTGEKPYT CKQCGKAFSV SGSLQRHETT HSAEKPYACQ QCGKAFHHLG SFQRHMIRHT
   361  GNGPHKCKIC GKGFDCPSSL QSHERTHTGE KPYECKQCGK ALSHRSSFRS HMIMHTGDGP
   421  HKCKVCGKAF VYPSVFQRHE RTHTAEKPYK CKQCGKAYRI SSSLRRHETT HTGEKPYKCK
   481  LGKACIDFCS FQNHKTTHTG EKPYECKECG KAFSRFRYLS RHKRTHTGEK PYECKTCRKA
   541  FGHYDNLKVH ERIHSGEKPY ECKECGKAFS WLTCFLRHER IHMREKSYEC PQCGKAFTHS
   601  RFLQGHEKTH TGENPYECKE CGKAFASLSS LHRHKKTHWK KTHTGENPYE CKECGKAFAS
   661  LSSLHRHKKT H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF443 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

breast: 3.9 nTPM
thymus: 3.7 nTPM
kidney: 3.6 nTPM
skin: 3.6 nTPM
basal ganglia: 3.4 nTPM
liver: 3.2 nTPM

Single-cell type

astrocytes: 5.3 nCPM
ependymal cells: 3.2 nCPM
microglia: 3.1 nCPM
brain inhibitory neurons: 2.9 nCPM
bergmann glia: 2.8 nCPM
brain excitatory neurons: 2.5 nCPM

Immune cell

MAIT T-cell: 3.7 nTPM
basophil: 2.5 nTPM
memory CD4 T-cell: 2.3 nTPM
memory CD8 T-cell: 2.2 nTPM
memory B-cell: 2.1 nTPM
naive CD4 T-cell: 1.9 nTPM

Brain region

cerebellum: 5.3 nTPM
thalamus: 5 nTPM
medulla oblongata: 4.7 nTPM
midbrain: 4.7 nTPM
cerebral cortex: 4.6 nTPM
amygdala: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: -1.34
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF443 as an antibody target. Whether an autoantibody or antibody against ZNF443 could matter depends on whether native ZNF443 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF443 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF443 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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