Seroatlas · Human Serome Atlas

ZNF442

Zinc finger protein 442

Also known as: FLJ14356, ZN442_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7R0
Gene: ZNF442
Ensembl: ENSG00000198342
Chromosome: 19
Canonical length: 627 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear membrane,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>Q9H7R0|ZNF442
     1  MIVFGGEDRS DLFLPDSQTN EERKQYDSVA FEDVAVNFTQ EEWALLGPSQ KSLYRDVMWE
    61  TIRNLDCIGM KWEDTNIEDQ HRNPRRSLRC HIIERFSESR QPDSTVNEKP PGVDPCKSSV
   121  CGEIMGCSFL NCYITFDAGH KPDECQEYGE KPHTHKQCGT AFNYHHSFQT QERPHTGKKR
   181  YDCKECGKTF SSSGNLRRHI IVQRGGGPYI CKLCGKAFFW PSLFRMHERT HTGEKPYECK
   241  QCCKAFPIYS SYLRHERTHT GEKPYECKHC SKAFPDYSSY VRHERTHTGE KPYKCKRCGR
   301  AFSVSSSLRI HERTHTGEKP YECKQCGKAF HHLGSFQRHM IRHTGDGPHK CKICGKGFDC
   361  PSSLQSHERT HTGEKPYECK QCGKALSHHS SFRSHMIMHT GDGPHKCKVC GKAFIYPSVF
   421  QGHERTHTGE KPYECKECGK AFRISSSLRR HETTHTGEKP YKCKCGKAFI DFYSFQNHET
   481  THTGEKPYEC KECGKAFSCF TYLSQHRRTH MAEKPYECKT CKKAFSHFGN LKVHERIHTG
   541  EKPYECKECR KAFSWLTCLL RHERIHTGKK SYECQQCGKA FTRSRFLRGH EKTHTGEKMH
   601  ECKECGKALS SLSSLHRHKR THWRDTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF442 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

ovary: 3.8 nTPM
blood vessel: 2.1 nTPM
fallopian tube: 2.1 nTPM
liver: 2 nTPM
urinary bladder: 2 nTPM
seminal vesicle: 1.9 nTPM

Single-cell type

ovarian stromal cells: 16 nCPM
retinal ganglion cells: 16 nCPM
podocytes: 14 nCPM
renal collecting duct principal cells: 13 nCPM
müller glia: 12 nCPM
retinal horizontal cells: 12 nCPM

Immune cell

memory B-cell: 2.5 nTPM
eosinophil: 2.2 nTPM
naive CD4 T-cell: 1.3 nTPM
gdT-cell: 0.8 nTPM
naive CD8 T-cell: 0.8 nTPM
neutrophil: 0.6 nTPM

Brain region

medulla oblongata: 24 nTPM
pons: 19 nTPM
thalamus: 16 nTPM
midbrain: 16 nTPM
choroid plexus: 15 nTPM
white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.03
gnomAD missense Z: -0.72
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF442 as an antibody target. Whether an autoantibody or antibody against ZNF442 could matter depends on whether native ZNF442 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF442 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF442 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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