Seroatlas · Human Serome Atlas

ZNF441

Zinc finger protein 441

Also known as: FLJ38637, ZN441_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8Z8
Gene: ZNF441
Ensembl: ENSG00000197044
Chromosome: 19
Canonical length: 693 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>Q8N8Z8|ZNF441
     1  MDSVAFEDVA INFTCEEWAL LGPSQKSLYR DVMQETIRNL DCIGMIWQNH DIEEDQYKDL
    61  RRNLRCHMVE RACEIKDNSQ CGGPFTQTQD SIVNEKIPGV DPWESSECTD VLMGRSSLNC
   121  YVRVDSEHKP CEYQEYGEKP YTHTQCGTAF SYQPCFQIHE RPQHGKKLYD CKECASFSSL
   181  ENLQRHMAAH HGDGPRICKL CGNAFIWPSL FHMLRRTHTE EKPYEYEQCS TAFPAYSSTL
   241  RHERTHSGEK PYQCKQCGKA FSCSCYTQLY ERTHTGEQSY ECKQCGKAFY HLGSFQRHMI
   301  VHTGDGPHKC KICGKGFLSP SSVRRHKRTH TGEKPYECKY CGKAFSDCTG FRRHMITHTG
   361  DGPHKCKVCG KAFDSPSLCR RHETTHTGEK PYKCECGKAF SDFYYFRNHE TTHTGEKPYK
   421  CKQCGKAFIC CTYLQIHERI HTGERPYKCK QCGKAFRSSN YIRVHEKTHT GEKPYECKQC
   481  GKALSHLKSF QRHMIMHTGD GPHKCKICGK SFDSPSSFRR HERIHTGERP YKCKLCGKGF
   541  RSSSYIQLHE RTHTGEKPYG CQQCGKALSD LSSFRRHMIT HTGNGPHKCK ICGKGFDYPS
   601  SVQRHERTHT GEKPYECKEC GKAFSHSSYL RIHERVHTGE KPYKCKECGK PFHCPSAFHK
   661  HERTHSMEKP YKCKECGEAF HCISSFHKHE MTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF441 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.4 nTPM
parathyroid gland: 6.8 nTPM
pituitary gland: 6.6 nTPM
retina: 6.6 nTPM
thyroid gland: 6.6 nTPM
basal ganglia: 6.5 nTPM

Single-cell type

myonuclei: 44 nCPM
bergmann glia: 37 nCPM
tuft cells: 35 nCPM
lactotrophs: 33 nCPM
rod photoreceptor cells: 33 nCPM
thyrotrophs: 27 nCPM

Immune cell

naive B-cell: 1.6 nTPM
naive CD8 T-cell: 1.6 nTPM
non-classical monocyte: 1.6 nTPM
memory CD8 T-cell: 1.5 nTPM
memory B-cell: 1.4 nTPM
naive CD4 T-cell: 1.4 nTPM

Brain region

cerebellum: 18 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 12 nTPM
white matter: 12 nTPM
hypothalamus: 11 nTPM
amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0.36
gnomAD missense Z: 1.56
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF441 as an antibody target. Whether an autoantibody or antibody against ZNF441 could matter depends on whether native ZNF441 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF441 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF441 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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