ZNF440

Protein identityUniProt · HPA

UniProt accession

Q8IYI8

Gene

ZNF440

Ensembl

ENSG00000171295

Chromosome

19

Canonical length

595 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q8IYI8|ZNF440
     1  MDPVAFKDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSLGKRWKDQ NIEYEHQNPR
    61  RNFRSLIEEK VNEIKDDSHC GETFTPVPDD RLNFQEKKAS PEVKSCESFV CGEVGLGNSS
   121  FNMNIRGDIG HKAYEYQEYG PKPCKCQQPK KAFRYRPSFR TQERDHTGEK PNACKVCGKT
   181  FISHSSVRRH MVMHSGDGPY KCKFCGKAFH CLRLYLIHER IHTGEKPCEC KQCGKSFSYS
   241  ATHRIHKRTH TGEKPYEYQE CGKAFHSPRS YRRHERIHMG EKAYQCKECG KAFTCPRYVR
   301  IHERTHSRKN LYECKQCGKA LSSLTSFQTH VRLHSGERPY ECKICGKDFC SVNSFQRHEK
   361  IHSGEKPYKC KQCGKAFPHS SSLRYHERTH TGEKPYECKQ CGKAFRSASH LRVHGRTHTG
   421  EKPYECKECG KAFRYVNNLQ SHERTQTHIR IHSGERRYKC KICGKGFYCP KSFQRHEKTH
   481  TGEKLYECKQ RSVVPSVVPV PFDIMKGLTL ERSPINASNV GKPSELCQSF ECMVGLTLKR
   541  NPMSVSNDGK PSDLPHTFEY VVGHTMERSP MHVRNVGNPS DLPRTFEFMK GHKHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF440 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

15 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.63

gnomAD pLI

0.01

gnomAD missense Z

-0.52

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• KRAB box
• C2H2-type zinc finger

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF440 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM28