Seroatlas · Human Serome Atlas

ZNF438

Zinc finger protein 438

Also known as: bA330O11.1, ZN438_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4V0
Gene: ZNF438
Ensembl: ENSG00000183621
Chromosome: 10
Canonical length: 828 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables DNA-binding transcription factor activity. Involved in negative regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

828 residues, UniProt reviewed canonical sequence.

>Q7Z4V0|ZNF438
     1  MQNSVSVPPK DEGESNIPSG TIQSRKGLQN KSQFRTIAPK IVPKVLTSRM LPCHSPSRSD
    61  QVNLGPSINS KLLGMSTQNY ALMQVAGQEG TFSLVALPHV ASAQPIQKPR MSLPENLKLP
   121  IPRYQPPRNS KASRKKPILI FPKSGCSKAP AQTQMCPQMS PSPPHHPELL YKPSPFEEVP
   181  SLEQAPASIS TAALTNGSDH GDLRPPVTNT HGSLNPPATP ASSTPEEPAK QDLTALSGKA
   241  HFVSKITSSK PSAVASEKFK EQVDLAKTMT NLSPTILGNA VQLISSVPKG KLPIPPYSRM
   301  KTMEVYKIKS DANIAGFSLP GPKADCDKIP STTEGFNAAT KVASRLPVPQ VSQQSACESA
   361  FCPPTKLDLN HKTKLNSGAA KRKGRKRKVP DEILAFQGKR RKYIINKCRD GKERVKNDPQ
   421  EFRDQKLGTL KKYRSIMPKP IMVIPTLASL ASPTTLQSQM LGGLGQDVLL NNSLTPKYLG
   481  CKQDNSSSPK PSSVFRNGFS GIKKPWHRCH VCNHHFQFKQ HLRDHMNTHT NRRPYSCRIC
   541  RKSYVRPGSL STHMKLHHGE NRLKKLMCCE FCAKVFGHIR VYFGHLKEVH RVVISTEPAP
   601  SELQPGDIPK NRDMSVRGME GSLERENKSN LEEDFLLNQA DEVKLQIKCG RCQITAQSFA
   661  EIKFHLLDVH GEEIEGRLQE GTFPGSKGTQ EELVQHASPD WKRHPERGKP EKVHSSSEES
   721  HACPRLKRQL HLHQNGVEML MENEGPQSGT NKPRETCQGP ECPGLHTFLL WSHSGFNCLL
   781  CAEMLGRKED LLHHWKHQHN CEDPSKLWAI LNTVSNQGVI ELSSEAEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF438 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 23 nTPM
tongue: 16 nTPM
blood vessel: 12 nTPM
adipose tissue: 12 nTPM
colon: 11 nTPM
heart muscle: 10 nTPM

Single-cell type

neutrophils: 1,434 nCPM
myonuclei: 350 nCPM
neutrophil progenitors: 289 nCPM
bergmann glia: 269 nCPM
choroid plexus epithelial cells: 239 nCPM
fibro-adipogenic progenitors: 230 nCPM

Immune cell

neutrophil: 13 nTPM
classical monocyte: 7.3 nTPM
intermediate monocyte: 7 nTPM
non-classical monocyte: 4.3 nTPM
NK-cell: 3.9 nTPM
naive B-cell: 3.7 nTPM

Brain region

cerebral cortex: 10 nTPM
thalamus: 10 nTPM
white matter: 10 nTPM
hypothalamus: 9.2 nTPM
choroid plexus: 8.8 nTPM
basal ganglia: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: -0.29
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF438 as an antibody target. Whether an autoantibody or antibody against ZNF438 could matter depends on whether native ZNF438 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF438 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF438 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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