Seroatlas · Human Serome Atlas

ZNF430

Zinc finger protein 430

Also known as: FLJ13659, ZN430_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8G1
Gene: ZNF430
Ensembl: ENSG00000118620
Chromosome: 19
Canonical length: 570 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in substantia nigra development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q9H8G1|ZNF430
     1  MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ CLDTAQQDLY
    61  RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH AMVDQPPVTY SHFAQDLWPE
   121  QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK SVDECNLHKE CYDELNQCLT TTQSEIFQYD
   181  KYVNVFYKFS NPNIQKIRHT GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK
   241  VFNWFSTLTR HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR
   301  SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC GKAFNQSSTL
   361  TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF YKCEECGKGF NWSSTLTKHK
   421  RIHTGEKPYK CEQCGKAFNE SSNLTAHKII HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS
   481  GEKPYKCEEC GKAFNQFSNL TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP
   541  YNCEEYGKAF NQSSNLIEQS NSYWRETLQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF430 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 11 nTPM
ovary: 11 nTPM
lymph node: 9.6 nTPM
thymus: 9.1 nTPM
epididymis: 8 nTPM
thyroid gland: 7.9 nTPM

Single-cell type

urothelial cells: 173 nCPM
esophageal apical cells: 130 nCPM
ocular epithelial cells: 111 nCPM
microglia: 53 nCPM
suprabasal keratinocytes: 53 nCPM
b-cells: 51 nCPM

Immune cell

basophil: 20 nTPM
eosinophil: 16 nTPM
naive CD4 T-cell: 14 nTPM
naive B-cell: 13 nTPM
T-reg: 11 nTPM
naive CD8 T-cell: 11 nTPM

Brain region

cerebellum: 27 nTPM
white matter: 23 nTPM
basal ganglia: 21 nTPM
medulla oblongata: 20 nTPM
pons: 20 nTPM
cerebral cortex: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0.01
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF430 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF430 as an antibody target. Whether an autoantibody or antibody against ZNF430 could matter depends on whether native ZNF430 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF430 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF430 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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