Seroatlas · Human Serome Atlas

ZNF429

Zinc finger protein 429

Also known as: ZN429_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86V71
Gene: ZNF429
Ensembl: ENSG00000197013
Chromosome: 19
Canonical length: 674 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q86V71|ZNF429
     1  MGPLTFTDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEKEK
    61  EPCKMKRHEM VDEPPVVCSH FAEDFWPEQD IKDSFQKVTL RRYDKRGHEN LQLRKGYKTV
   121  GDCKLYKGGY NGLNQCLTLT QSKMYHCDIY VKVFYAFSNA DRYKTRHTGK KPFQCKKCGK
   181  SFCMLSQLTQ HKKIHIRENT YRCKEFGNAF NQSSALTNHK RIYVGEKHYR CEECGKAFNH
   241  YSTLTNHKRI HTGEKPYKCK ECGKAFSRYS TLTTHKRIHS GEKPYKCDEC GKTFSISSTF
   301  TKHKIIHTEE KPYKCKECGK AFNRSSTLTS HKRIHTGEKP YKCEECGKAF NWSSTLTKHK
   361  VIHTGEKPYK CEECGKAFNQ SSRLTRHKKI HTGEEPYKFE KCGRVFTCSS TLTQDKKIHT
   421  GEKPYNCEEC GKVFTYSSTL TRHKRIHTEE KPYKCNECGK AFNRSSHLTS HRRIHTGEKP
   481  YKCEECGKAF KQSSNLNSHK KIHSGEKPYK CEECGKAFIL SSRLTQHKKI HTGEKPYKCE
   541  ECGKAFNRSS RLTQHKKIHT GEKPYKCKQC DKAFTHSSNL SSHKKIHSGE KPYKCEECGK
   601  AFNRSSRLTQ HKKIHTREKP YKCEECAKAF TRSSRLTQHK KIHRMGVVAH ACNPSTLGGR
   661  GGRITRSGDR DRPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF429 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 7.2 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 7.2 nTPM
skin: 6 nTPM
epididymis: 5.6 nTPM
ovary: 5.6 nTPM
spleen: 5.4 nTPM
thymus: 5.3 nTPM

Single-cell type

neutrophils: 490 nCPM
choroid plexus epithelial cells: 89 nCPM
thyrotrophs: 73 nCPM
adipocytes: 72 nCPM
tuft cells: 69 nCPM
adrenal cortex cells: 67 nCPM

Immune cell

basophil: 6.3 nTPM
neutrophil: 5.6 nTPM
NK-cell: 4.6 nTPM
naive CD4 T-cell: 4.5 nTPM
naive CD8 T-cell: 4.3 nTPM
eosinophil: 4.2 nTPM

Brain region

cerebellum: 37 nTPM
white matter: 35 nTPM
cerebral cortex: 34 nTPM
amygdala: 33 nTPM
basal ganglia: 32 nTPM
choroid plexus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -0.99
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF429 as an antibody target. Whether an autoantibody or antibody against ZNF429 could matter depends on whether native ZNF429 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF429 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF429 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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