Seroatlas · Human Serome Atlas

ZNF428

Zinc finger protein 428

Also known as: C19orf37, MGC51082, Zfp428, ZN428_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96B54
Gene: ZNF428
Ensembl: ENSG00000131116
Chromosome: 19
Canonical length: 188 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitochondria

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q96B54|ZNF428
     1  MTETREPAET GGYASLEEDD EDLSPGPEHS SDSEYTLSEP DSEEEEDEEE EEEETTDDPE
    61  YDPGYKVKQR LGGGRGGPSR RAPRAAQPPA QPCQLCGRSP LGEAPPGTPP CRLCCPATAP
   121  QEAPAPEGRA LGEEEEEPPR AGEGRPAGRE EEEEEEEEGT YHCTECEDSF DNLGELHGHF
   181  MLHARGEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF428 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 116 nTPM

Expression across tissuesHPA

Tissue

amygdala: 116 nTPM
basal ganglia: 114 nTPM
cerebral cortex: 114 nTPM
hippocampal formation: 101 nTPM
hypothalamus: 93 nTPM
midbrain: 93 nTPM

Single-cell type

undifferentiated spermatogonia: 296 nCPM
cytotrophoblasts: 179 nCPM
early spermatids: 176 nCPM
granulosa cells: 169 nCPM
oocytes: 161 nCPM
decidual stromal cells: 160 nCPM

Immune cell

eosinophil: 9.3 nTPM
gdT-cell: 6.2 nTPM
naive B-cell: 6.2 nTPM
memory CD8 T-cell: 6.1 nTPM
naive CD4 T-cell: 5.9 nTPM
plasmacytoid DC: 5.7 nTPM

Brain region

thalamus: 103 nTPM
cerebral cortex: 99 nTPM
hypothalamus: 93 nTPM
amygdala: 90 nTPM
basal ganglia: 86 nTPM
hippocampal formation: 86 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.5
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
Zinc finger protein 428

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF428 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF428 as an antibody target. Whether an autoantibody or antibody against ZNF428 could matter depends on whether native ZNF428 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF428 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF428 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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