Seroatlas · Human Serome Atlas

ZNF426

Zinc finger protein 426

Also known as: MGC2663, ZN426_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUY5
Gene: ZNF426
Ensembl: ENSG00000130818
Chromosome: 19
Canonical length: 554 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

554 residues, UniProt reviewed canonical sequence.

>Q9BUY5|ZNF426
     1  MAAADLSHGH YLSGDPVCLH EEKTPAGRIV ADCLTDCYQD SVTFDDVAVD FTQEEWTLLD
    61  STQRSLYSDV MLENYKNLAT VGGQIIKPSL ISWLEQEESR TVQGGVLQGW EMRLETQWSI
   121  LQQDFLRGQT SIGIQLEGKH NGRELCDCEQ CGEVFSEHSC LKTHVRTQST GNTHDCNQYG
   181  KDFLTLCEKT STGEKLSEFN QSEKIFSLTP NIVYQRTSTQ EKSFECSHCG KSFINESYLQ
   241  AHMRTHNGEK LYEWRNYGPG FIDSTSLSVL IETLNAKKPY KCKECGKGYR YPAYLSIHMR
   301  THTGEKPYEC KECGKAFNYS NSFQIHGRTH TGEKPYVCKE CGKAFTQYSG LSMHVRSHSG
   361  DKPYECKECG KSFLTSSRLI QHIRTHTGEK PFVCVECGKA FAVSSNLSGH LRTHTEEKAC
   421  ECKICGKVFG YPSCLNNHMR THSAQKPYTC KECGKAFNYS THLKIHMRIH TGEKPYECKQ
   481  CGKAFSHSSS FQIHERTHTG EKPYECKECG KAFTCSSSFR IHEKTHTEEK PYKCQQCGKA
   541  YSHPRSLRRH EQIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF426 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

esophagus: 19 nTPM
ovary: 7.6 nTPM
smooth muscle: 7.2 nTPM
endometrium: 7.1 nTPM
breast: 6.5 nTPM
thyroid gland: 6.3 nTPM

Single-cell type

esophageal apical cells: 414 nCPM
early spermatids: 42 nCPM
esophageal suprabasal cells: 39 nCPM
epididymal clear cells: 39 nCPM
epididymal basal cells: 37 nCPM
epididymal principal cells: 36 nCPM

Immune cell

naive CD4 T-cell: 10 nTPM
basophil: 9.9 nTPM
naive CD8 T-cell: 9.3 nTPM
gdT-cell: 8.8 nTPM
memory CD8 T-cell: 8.7 nTPM
MAIT T-cell: 7.8 nTPM

Brain region

white matter: 22 nTPM
cerebellum: 22 nTPM
choroid plexus: 21 nTPM
basal ganglia: 19 nTPM
thalamus: 19 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF426 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

OPTN

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF426 as an antibody target. Whether an autoantibody or antibody against ZNF426 could matter depends on whether native ZNF426 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF426 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF426 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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