Seroatlas · Human Serome Atlas

ZNF425

Zinc finger protein 425

Also known as: ZN425_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IV72
Gene: ZNF425
Ensembl: ENSG00000204947
Chromosome: 7
Canonical length: 752 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

752 residues, UniProt reviewed canonical sequence.

>Q6IV72|ZNF425
     1  MAEPASVTVT FDDVALYFSE QEWEILEKWQ KQMYKQEMKT NYETLDSLGY AFSKPDLITW
    61  MEQGRMLLIS EQGCLDKTRR TTSPPTDEQL NMKNTGKLLC FDDEGTPRTK EEDCRLNGPQ
   121  KQDLCAALRG KERKILLAQT ATFQSPSLRE TEILNKKVSI TAYDPDKKDL RHKPRETPGR
   181  LEIPTGPRCY SCYVCRKVFQ VRRDLLKHKR SHSKSQLCRY PKYKNSSRGK SELRRTQRLL
   241  CQKKRFQCSE CEKSYFLKGS LVTHQVVHTG QRPYPCPECD KTFRYRANLK KHLCLHRGER
   301  PFCCGECGRA FVQQCELTEH LRLHSGEKPF QCPQCDRCFR LKRGMKVHLT QHSGKRPFHC
   361  PECGRSFSRK AALKTHQRTH SEEKPFSCGE CGRKFIYKIK LDEHIRVHTG EKPFSCPECN
   421  KSFRLKRSLK AHGLQHIGKR PFQCPECSRG FFWRNAMRAH QRLHSEQKPF PCAECGKRFT
   481  RPSKLACHTR VHDRQKEFPC GECKKTFSQQ SRLTQHLKVH TTEKPFSCAE CGRSFRRRAH
   541  LTEHTRLHSG EEPFQCPECD KSFSWKASMK FHQRMHRDEK PFACGECDKT YTHQSQLTEH
   601  LRLHSGEKPY QCPECEKTFR LKGNLKSHLL QHSGQKPFSC VMCGKSFTQQ YRLTEHIRVH
   661  SGEKPFQCPE CDKSYCIRGS LKVHLYKHSG ERPFQCPECG KGFLQKRSLK AHLCLHSGER
   721  PFSCDECGRS FTYVGALKTH IAVHAKEKPS SL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF425 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 3.5 nTPM
cerebral cortex: 3.3 nTPM
cerebellum: 3.2 nTPM
ovary: 3.1 nTPM
basal ganglia: 2.7 nTPM
amygdala: 2.5 nTPM

Single-cell type

retinal ganglion cells: 46 nCPM
tuft cells: 23 nCPM
adrenal medulla cells: 21 nCPM
myonuclei: 19 nCPM
bergmann glia: 18 nCPM
oocytes: 18 nCPM

Immune cell

NK-cell: 3.2 nTPM
MAIT T-cell: 2.3 nTPM
naive CD8 T-cell: 2.3 nTPM
basophil: 2.1 nTPM
naive CD4 T-cell: 2.1 nTPM
plasmacytoid DC: 2.1 nTPM

Brain region

cerebellum: 7.3 nTPM
cerebral cortex: 7.1 nTPM
basal ganglia: 7 nTPM
hypothalamus: 6.5 nTPM
midbrain: 6.5 nTPM
amygdala: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF425 as an antibody target. Whether an autoantibody or antibody against ZNF425 could matter depends on whether native ZNF425 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF425 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF425 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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