Seroatlas · Human Serome Atlas

ZNF419

Zinc finger protein 419

Also known as: ZAPHIR, ZN419_HUMAN, ZNF419A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HQ0
Gene: ZNF419
Ensembl: ENSG00000105136
Chromosome: 19
Canonical length: 510 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q96HQ0|ZNF419
     1  MAAAALRDPA QVPVAADLLT DHEEGYVTFE DVAVYFSQEE WRLLDDAQRL LYRNVMLENF
    61  TLLASLGLAS SKTHEITQLE SWEEPFMPAW EVVTSAIPRG CWHGAEAEEA PEQIASVGLL
   121  SSNIQQHQKQ HCGEKPLKRQ EGRVPVLRSC KVHLSEKSLQ SREVGKALLI SSGVLKHQVT
   181  HTGEKSHRSS KSREAFHAGK RHYKCSECGK AFGQKYLLVQ HQRLHAGKKT YECSECGKLF
   241  RDMSNLFIHQ IVHTGERPYG CSNCGKSFSR NAHLIEHQRV HTGEKPFTCS ECGKAFRHNS
   301  TLVQHHKIHT GVRPYECSEC GKLFSFNSSL MKHQRIHTGE RPYKCSECGK FYSHKSNLIK
   361  HWRVHTGERP YKCSDCGKFF TQCSSLMQHQ KVHTGEKPFK CNECGRFFRE NSTLVRHQRV
   421  HTGAKPYECR ECGKFFSQSS TLMQHRKVHI GEKPFKCNEC GRLFRENSSL VKHQRVHTGA
   481  KPYECRECGK FFRHNSSLFK HRRIHTGEMQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF419 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 13 nTPM
pituitary gland: 13 nTPM
choroid plexus: 11 nTPM
spleen: 10 nTPM
thyroid gland: 10 nTPM
retina: 10 nTPM

Single-cell type

parietal cells: 3.5 nCPM
epididymal principal cells: 1.7 nCPM
epididymal basal cells: 1.1 nCPM
breast hormone-responsive cells: 1 nCPM
suprabasal keratinocytes: 0.8 nCPM
epididymal efferent duct absorptive cells: 0.7 nCPM

Immune cell

naive B-cell: 16 nTPM
memory B-cell: 14 nTPM
naive CD4 T-cell: 14 nTPM
NK-cell: 9.7 nTPM
MAIT T-cell: 9 nTPM
memory CD4 T-cell: 9 nTPM

Brain region

cerebellum: 14 nTPM
cerebral cortex: 13 nTPM
thalamus: 13 nTPM
basal ganglia: 13 nTPM
hippocampal formation: 13 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0.01
gnomAD missense Z: -1.79
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF419 as an antibody target. Whether an autoantibody or antibody against ZNF419 could matter depends on whether native ZNF419 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF419 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF419 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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