Seroatlas · Human Serome Atlas

ZNF418

Zinc finger protein 418

Also known as: FLJ31551, KIAA1956, ZN418_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF45
Gene: ZNF418
Ensembl: ENSG00000196724
Chromosome: 19
Canonical length: 676 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity. Predicted to be involved in microautophagy; regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of transcription by RNA polymerase II. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

676 residues, UniProt reviewed canonical sequence.

>Q8TF45|ZNF418
     1  MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS EDEEAPSKKS
    61  ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH QGTHHKQKLH RCEAWGNKLY
   121  DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC KFHVSEESSI FIQSGKDFLP SSGLLLQEAT
   181  HTGEKSNSKP ECESPFQWGD THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS
   241  KYDSVSNHQR VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS
   301  LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC FTQKGNLIQH
   361  QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC GECGKSFSRK GHLRNHQRGH
   421  TGERPYECGE CGKSFSRKGN LIQHQRSHTG ERPYECRECR KLFRGKSHLI EHQRVHTGER
   481  PYECNECGKS FQDSSGFRVH QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC
   541  GECGKSFHQS SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF
   601  TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS ECGKSFHRSS
   661  SLLRHQRVHT ERSPYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF418 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

retina: 12 nTPM
cerebellum: 9 nTPM
skin: 8.5 nTPM
heart muscle: 8.2 nTPM
thyroid gland: 6.3 nTPM
parathyroid gland: 5.8 nTPM

Single-cell type

cardiomyocytes: 22 nCPM
distal convoluted tubule cells: 15 nCPM
lactotrophs: 13 nCPM
renal connecting tubule cells: 13 nCPM
thyrotrophs: 12 nCPM
pituitary stem cells: 12 nCPM

Immune cell

naive B-cell: 5.6 nTPM
NK-cell: 4.3 nTPM
memory B-cell: 3.3 nTPM
naive CD4 T-cell: 1.8 nTPM
plasmacytoid DC: 1.8 nTPM
basophil: 1.3 nTPM

Brain region

cerebellum: 41 nTPM
white matter: 37 nTPM
cerebral cortex: 31 nTPM
hypothalamus: 31 nTPM
amygdala: 29 nTPM
basal ganglia: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF418.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 117 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Moyamoya angiopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.37
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF418 as an antibody target. Whether an autoantibody or antibody against ZNF418 could matter depends on whether native ZNF418 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF418 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF418 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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