Seroatlas · Human Serome Atlas

ZNF416

Zinc finger protein 416

Also known as: FLJ20557, ZN416_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWM5
Gene: ZNF416
Ensembl: ENSG00000083817
Chromosome: 19
Canonical length: 594 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in microautophagy; regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cardiac muscle hypertrophy; negative regulation of cell growth involved in cardiac muscle cell development; and negative regulation of protein phosphorylation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q9BWM5|ZNF416
     1  MAAAVLRDST SVPVTAEAKL MGFTQGCVTF EDVAIYFSQE EWGLLDEAQR LLYRDVMLEN
    61  FALITALVCW HGMEDEETPE QSVSVEGVPQ VRTPEASPST QKIQSCDMCV PFLTDILHLT
   121  DLPGQELYLT GACAVFHQDQ KHHSAEKPLE SDMDKASFVQ CCLFHESGMP FTSSEVGKDF
   181  LAPLGILQPQ AIANYEKPNK ISKCEEAFHV GISHYKWSQC RRESSHKHTF FHPRVCTGKR
   241  LYESSKCGKA CCCECSLVQL QRVHPGERPY ECSECGKSFS QTSHLNDHRR IHTGERPYVC
   301  GQCGKSFSQR ATLIKHHRVH TGERPYECGE CGKSFSQSSN LIEHCRIHTG ERPYECDECG
   361  KAFGSKSTLV RHQRTHTGEK PYECGECGKL FRQSFSLVVH QRIHTTARPY ECGQCGKSFS
   421  LKCGLIQHQL IHSGARPFEC DECGKSFSQR TTLNKHHKVH TAERPYVCGE CGKAFMFKSK
   481  LVRHQRTHTG ERPFECSECG KFFRQSYTLV EHQKIHTGLR PYDCGQCGKS FIQKSSLIQH
   541  QVVHTGERPY ECGKCGKSFT QHSGLILHRK SHTVERPRDS SKCGKPYSPR SNIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF416 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

skin: 4.9 nTPM
ovary: 4.3 nTPM
parathyroid gland: 4.1 nTPM
testis: 4 nTPM
tonsil: 3.9 nTPM
epididymis: 3.7 nTPM

Single-cell type

esophageal apical cells: 27 nCPM
oocytes: 18 nCPM
late primary spermatocytes: 8.6 nCPM
epididymal clear cells: 6.1 nCPM
esophageal suprabasal cells: 5.6 nCPM
undifferentiated spermatogonia: 5.1 nCPM

Immune cell

naive B-cell: 10 nTPM
NK-cell: 9 nTPM
naive CD4 T-cell: 8 nTPM
MAIT T-cell: 7.8 nTPM
memory B-cell: 6.6 nTPM
memory CD8 T-cell: 6.3 nTPM

Brain region

cerebellum: 8.7 nTPM
basal ganglia: 6 nTPM
white matter: 5.6 nTPM
cerebral cortex: 5.5 nTPM
hypothalamus: 5.2 nTPM
hippocampal formation: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.37
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF416 as an antibody target. Whether an autoantibody or antibody against ZNF416 could matter depends on whether native ZNF416 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF416 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF416 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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