Seroatlas · Human Serome Atlas

ZNF415

Zinc finger protein 415

Also known as: ZN415_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q09FC8
Gene: ZNF415
Ensembl: ENSG00000170954
Chromosome: 19
Canonical length: 603 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center,Microtubules

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in fibrillar center and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

603 residues, UniProt reviewed canonical sequence.

>Q09FC8|ZNF415
     1  MPELYTEDFI QGCDVGELQE PGLPGVLSYV GAQERALDHR KPSTSSKKTK RVEIDQRCEN
    61  RLECNGAISA HCNLRLPDSN DSPASASRVA GITDLSRNCV IKELAPQQEG NPGEVFHTVT
   121  LEQHEKHDIE EFCFREIKKK IHDFDCQWRD DERNCNKVTT APKENLTCRR DQRDRRGIGN
   181  KSIKHQLGLS FLPHPHELQQ FQAEGKIYEC NHVEKSVNHG SSVSPPQIIS STIKTHVSNK
   241  YGTDFICSSL LTQEQKSCIR EKPYRYIECD KALNHGSHMT VRQVSHSGEK GYKCDLCGKV
   301  FSQKSNLARH WRVHTGEKPY KCNECDRSFS RNSCLALHRR VHTGEKPYKC YECDKVFSRN
   361  SCLALHQKTH IGEKPYTCKE CGKAFSVRST LTNHQVIHSG KKPYKCNECG KVFSQTSSLA
   421  THQRIHTGEK PYKCNECGKV FSQTSSLARH WRIHTGEKPY KCNECGKVFS YNSHLASHRR
   481  VHTGEKPYKC NECGKAFSVH SNLTTHQVIH TGEKPYKCNQ CGKGFSVHSS LTTHQVIHTG
   541  EKPYKCNECG KSFSVRPNLT RHQIIHTGKK PYKCSDCGKS FSVRPNLFRH QIIHTKEKPY
   601  KRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF415 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
adrenal gland: 17 nTPM
heart muscle: 16 nTPM
cerebellum: 15 nTPM
epididymis: 13 nTPM
midbrain: 13 nTPM

Single-cell type

early spermatids: 93 nCPM
late primary spermatocytes: 88 nCPM
late spermatids: 68 nCPM
cardiomyocytes: 23 nCPM
oocytes: 23 nCPM
sertoli cells: 20 nCPM

Immune cell

eosinophil: 4.1 nTPM
memory B-cell: 4.1 nTPM
naive B-cell: 4.1 nTPM
basophil: 3.7 nTPM
NK-cell: 3.4 nTPM
plasmacytoid DC: 2.7 nTPM

Brain region

white matter: 55 nTPM
cerebellum: 39 nTPM
basal ganglia: 36 nTPM
hypothalamus: 35 nTPM
cerebral cortex: 34 nTPM
pons: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.22
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF415 as an antibody target. Whether an autoantibody or antibody against ZNF415 could matter depends on whether native ZNF415 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF415 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF415 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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