Seroatlas · Human Serome Atlas

ZNF414

Zinc finger protein 414

Also known as: MGC15716, Zfp414, ZN414_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IQ9
Gene: ZNF414
Ensembl: ENSG00000133250
Chromosome: 19
Canonical length: 312 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q96IQ9|ZNF414
     1  MEEKPSGPIP DMLATAEPSS SETDKEVLSP AVPAAAPSSS MSEEPGPEQA ATPPVWERGG
    61  AGGMQQGSSP APDSCQPGPG PSPGLTSIVS GTSEDLRPPR RRPPPGKQIP CSSPGCCLSF
   121  PSVRDLAQHL RTHCPPTQSL EGKLFRCSAL SCTETFPSMQ ELVAHSKLHY KPNRYFKCEN
   181  CLLRFRTHRS LFKHLHVCAE HAQSPAPPPP PALDREPPAP ERPPEVDPAS APGLPFPLLE
   241  PFTTPAPAPT GPFLPYLNPA PFGLSPPRLR PFLAAAPGPP ASSAAVWKKS QGAGSSPRRP
   301  QGGSDAPSGA CR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF414 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

prostate: 23 nTPM
cerebellum: 22 nTPM
endometrium: 22 nTPM
ovary: 22 nTPM
thyroid gland: 22 nTPM
skin: 21 nTPM

Single-cell type

oocytes: 166 nCPM
late spermatids: 150 nCPM
undifferentiated spermatogonia: 40 nCPM
esophageal apical cells: 38 nCPM
syncytiotrophoblasts: 37 nCPM
differentiating spermatogonia: 36 nCPM

Immune cell

neutrophil: 1.4 nTPM
basophil: 1.2 nTPM
plasmacytoid DC: 1.2 nTPM
memory CD4 T-cell: 0.9 nTPM
memory B-cell: 0.8 nTPM
memory CD8 T-cell: 0.8 nTPM

Brain region

white matter: 35 nTPM
medulla oblongata: 29 nTPM
cerebral cortex: 28 nTPM
thalamus: 28 nTPM
pons: 27 nTPM
basal ganglia: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.06
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
C2H2-type zinc ribbon
Zinc finger protein 414
C2H2-type zinc ribbon

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF414 as an antibody target. Whether an autoantibody or antibody against ZNF414 could matter depends on whether native ZNF414 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF414 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF414 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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