Seroatlas · Human Serome Atlas

ZNF41

Zinc finger protein 41

Also known as: MGC8941, MRX89, ZNF41_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51814
Gene: ZNF41
Ensembl: ENSG00000147124
Chromosome: X
Canonical length: 821 aa
Protein class: Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that contains KRAB-A and KRAB-B domains multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. An initial study suggested that this gene may be associated with X-linked cognitive disability, but a later study has called this finding into question (PMID:23871722).[provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

821 residues, UniProt reviewed canonical sequence.

>P51814|ZNF41
     1  MAANGDSPPW SPALAAEGRG SSCEVRRERT PEARIHSVKR YPDLSPGPKG RSSADHAALN
    61  SIVSLQASVS FEDVTVDFSK EEWQHLDPAQ RRLYWDVTLE NYSHLLSVGY QIPKSEAAFK
   121  LEQGEGPWML EGEAPHQSCS GEAIGKMQQQ GIPGGIFFHC ERFDQPIGED SLCSILEELW
   181  QDNDQLEQRQ ENQNNLLSHV KVLIKERGYE HKNIEKIIHV TTKLVPSIKR LHNCDTILKH
   241  TLNSHNHNRN SATKNLGKIF GNGNNFPHSP SSTKNENAKT GANSCEHDHY EKHLSHKQAP
   301  THHQKIHPEE KLYVCTECVM GFTQKSHLFE HQRIHAGEKS RECDKSNKVF PQKPQVDVHP
   361  SVYTGEKPYL CTQCGKVFTL KSNLITHQKI HTGQKPYKCS ECGKAFFQRS DLFRHLRIHT
   421  GEKPYECSEC GKGFSQNSDL SIHQKTHTGE KHYECNECGK AFTRKSALRM HQRIHTGEKP
   481  YVCADCGKAF IQKSHFNTHQ RIHTGEKPYE CSDCGKSFTK KSQLHVHQRI HTGEKPYICT
   541  ECGKVFTHRT NLTTHQKTHT GEKPYMCAEC GKAFTDQSNL IKHQKTHTGE KPYKCNGCGK
   601  AFIWKSRLKI HQKSHIGERH YECKDCGKAF IQKSTLSVHQ RIHTGEKPYV CPECGKAFIQ
   661  KSHFIAHHRI HTGEKPYECS DCGKCFTKKS QLRVHQKIHT GEKPNICAEC GKAFTDRSNL
   721  ITHQKIHTRE KPYECGDCGK TFTWKSRLNI HQKSHTGERH YECSKCGKAF IQKATLSMHQ
   781  IIHTGKKPYA CTECQKAFTD RSNLIKHQKM HSGEKRYKAS D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 17 nTPM
tongue: 15 nTPM
retina: 8.6 nTPM
heart muscle: 8.1 nTPM
parathyroid gland: 7.7 nTPM
thymus: 6.6 nTPM

Single-cell type

cardiomyocytes: 150 nCPM
myonuclei: 84 nCPM
choroid plexus epithelial cells: 41 nCPM
microglia: 30 nCPM
adipocytes: 29 nCPM
rod photoreceptor cells: 29 nCPM

Immune cell

naive B-cell: 4.2 nTPM
MAIT T-cell: 3.9 nTPM
myeloid DC: 3.6 nTPM
memory CD8 T-cell: 3.5 nTPM
naive CD4 T-cell: 3.4 nTPM
NK-cell: 3.4 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 13 nTPM
thalamus: 12 nTPM
choroid plexus: 12 nTPM
white matter: 12 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.04
gnomAD missense Z: 1.3
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF41 as an antibody target. Whether an autoantibody or antibody against ZNF41 could matter depends on whether native ZNF41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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