Seroatlas · Human Serome Atlas

ZNF407

Zinc finger protein 407

Also known as: FLJ13839, FLJ20307, KIAA1703, ZN407_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0G0
Gene: ZNF407
Ensembl: ENSG00000215421
Chromosome: 18
Canonical length: 2248 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

2248 residues, UniProt reviewed canonical sequence.

>Q9C0G0|ZNF407
     1  MMDSENKPEN DEDEKINKEA QDLTKLSSHN EDGGPVSDVI ASFPENSMGK RGFSESSNSD
    61  SVVIGEDRNK HASKRRKLDE AEPLKSGKQG ICRLETSESS VTEGGIALDE TGKETFLSDC
   121  TVGGTCLPNA LSPSCNFSTI DVVSLKTDTE KTSAQEMVSL DLERESPFPP KEISVSCTIG
   181  NVDTVLKCSI CGHLFSSCSD LEKHAESHMQ QPKEHTCCHC SHKAESSSAL HMHIKQAHGP
   241  QKVFSCDLCG FQCSEENLLN AHYLGKTHLR RQNLAARGGF VQILTKQPFP KKSRTMATKN
   301  VHSKPRTSKS IAKNSDSKGL RNVGSTFKDF RGSISKQSGS SSELLVEMMP SRNTLSQEVE
   361  IVEEHVTSLG LAQNPENQSR KLDTLVTSEG LLEKLESTKN TLQAAHGNSV TSRPRPERNI
   421  LVLGNSFRRR SSTFTLKGQA KKRFNLLGIK RGTSETQRMY MKHLRTQMKT HDAESVLKHL
   481  EACSSVQRVC VTTSETQEAE QGQGSARPPD SGLHSLTVKP ASGSQTLCAC TDCGQVATNR
   541  TDLEIHVKRC HAREMKFYCR TCDFSSMSRR DLDEHLHSNQ HQQTASVLSC QCCSFISLDE
   601  INLRDHMKEK HNMHFLCTPC NLFFLSEKDV EEHKATEKHI NSLVQPKTLQ SSNSDLVLQT
   661  LPLSTLESEN AKESMDDSGK ASQEEPLKSR VSHGNEVRHS SKPQFQCKKC FYKTRSSTVL
   721  TRHIKLRHGQ DYHFLCKACN LYSLSKEGME KHIKRSKHLE NAKKNNIGLS FEECIERVCI
   781  GANDKKEEFD VSGNGRIEGH IGVQLQEHSY LEKGMLASEE LSQSGGSTKD DELASTTTPK
   841  RGRPKGNISR TCSHCGLLAS SITNLTVHIR RKHSHQYSYL CKVCKYYTVT KGDMERHCAT
   901  KKHKGRVEIE ASGKHSSDII VGPEGGSLEA GKKNAGSAVT MSDEHANKPA ESPTSVLEKP
   961  DRGNSIEAEV ENVFHSLDGE VNSHLLDKKE QISSEPEDFA QPGDVYSQRD VTGTGENKCL
  1021  HCEFSAHSSA SLELHVKRKH TKEFEFYCMA CDYYAVTRRE MTRHAATEKH KMKRQSYLNS
  1081  ANVEAGSADM SKNIIMPEEE HQQNSEEFQI ISGQPSDTLK SRNAADCSIL NENTNLDMSK
  1141  VLCAADSVEV ETEEESNFNE DHSFCETFQQ APVKDKVRKP EEMMSLTMSS NYGSPSRFQN
  1201  ENSGSSALNC ETAKKNHEIS NDAGELRVHC EGEGGNAGDG GGVVPHRHLC PVTLDGERSA
  1261  ESPVLVVTRI TREQGNLESG GQNRVARGHG LEDLKGVQED PVLGNKEILM NSQHETEFIL
  1321  EEDGPASDST VESSDVYETI ISIDDKGQAM YSFGRFDSSI IRIKNPEDGE LIDQSEEGLI
  1381  ATGVRISELP LKDCAQGVKK KKSEGSSIGE STRIRCDDCG FLADGLSGLN VHIAMKHPTK
  1441  EKHFHCLLCG KSFYTESNLH QHLASAGHMR NEQASVEELP EGGATFKCVK CTEPFDSEQN
  1501  LFLHIKGQHE ELLREVNKYI VEDTEQINRE REENQGNVCK YCGKMCRSSN SMAFLAHIRT
  1561  HTGSKPFKCK ICHFATAQLG DARNHVKRHL GMREYKCHVC GVAFVMKKHL NTHLLGKHGV
  1621  GTPKERKFTC HLCDRSFTEK WALNNHMKLH TGEKPFKCTW PTCHYSFLTA SAMKDHYRTH
  1681  TGEKSFLCDL CGFAGGTRHA LTKHRRQHTG EKPFKCDECN FASTTQSHLT RHKRVHTGEK
  1741  PYRCPWCDYR SNCAENIRKH ILHTGKHEGV KMYNCPKCDY GTNVPVEFRN HLKEQHPDIE
  1801  NPDLAYLHAG IVSKSYECRL KGQGATFVET DSPFTAAALA EEPLVKEKPL RSSRRPAPPP
  1861  EQVQQVIIFQ GYDGEFALDP SVEETAAATL QTLAMAGQVA RVVHITEDGQ VIATSQSGAH
  1921  VGSVVPGPIL PEQLADGATQ VVVVGGSMEG HGMDESLSPG GAVIQQVTKQ EILNLSEAGV
  1981  APPEASSALD ALLCAVTELG EVEGRAGLEE QGRPGAKDVL IQLPGQEVSH VAADPEAPEI
  2041  QMFPQAQESP AAVEVLTQVV HPSAAMASQE RAQVAFKKMV QGVLQFAVCD TAAAGQLVKD
  2101  GVTQVVVSEE GAVHMVAGEG AQIIMQEAQG EHMDLVESDG EISQIIVTEE LVQAMVQESS
  2161  GGFSEGTTHY ILTELPPGVQ DEPGLYSHTV LETADSQELL QAGATLGTEA GAPSRAEQLA
  2221  SVVIYTQEGS SAAAAIQSQR ESSELQEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF407 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 4.9 nTPM
thymus: 4.8 nTPM
skeletal muscle: 3.6 nTPM
testis: 3.6 nTPM
ovary: 3.5 nTPM
parathyroid gland: 3.5 nTPM

Single-cell type

neutrophils: 573 nCPM
neutrophil progenitors: 545 nCPM
choroid plexus epithelial cells: 526 nCPM
somatotrophs: 287 nCPM
cardiomyocytes: 281 nCPM
myonuclei: 279 nCPM

Immune cell

neutrophil: 2.1 nTPM
basophil: 1.5 nTPM
plasmacytoid DC: 1.3 nTPM
NK-cell: 1.1 nTPM
gdT-cell: 1 nTPM
naive CD8 T-cell: 1 nTPM

Brain region

choroid plexus: 29 nTPM
cerebellum: 28 nTPM
pons: 20 nTPM
white matter: 19 nTPM
thalamus: 19 nTPM
basal ganglia: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF407.

Disease | AllUniProt

Conditions ZNF407 is implicated in, by any mechanism.

Short stature, impaired intellectual development, microcephaly, hypotonia, and ocular anomalies (SIMHA) MIM:619557

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 554 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature, impaired intellectual development, microcephaly, hypotonia, and ocular anomalies
Neurodevelopmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.09
gnomAD pLI: 1
gnomAD missense Z: 0.86
DepMap mean gene effect: -0.79
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF407 as an antibody target. Whether an autoantibody or antibody against ZNF407 could matter depends on whether native ZNF407 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF407 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF407 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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