ZNF391
Zinc finger protein 391
Also known as: dJ153G14.3, ZN391_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UJN7
- Gene
- ZNF391
- Ensembl
- ENSG00000124613
- Chromosome
- 6
- Canonical length
- 358 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
358 residues, UniProt reviewed canonical sequence.
>Q9UJN7|ZNF391
1 MESLRGNTAQ GPTNEEDYKN EGQLSRQTKC PAQKKSSFEN TVVRKVSVTL KEIFTGEEGP
61 ESSEFSLSPN LDAQQKIPKG HGSPISRKNS KDNSDLIKHQ RLFSQRKPCK CNECEKAFSY
121 QSDLLVHSRI HGGEKPFECN KCGKSFSRST HLIEHQRTHT GEKPYECNEC GKAFSRSTHL
181 SLHQRIHTGE KPYECSECGK AFSRSTNLSQ HQRTHTQERP YKCNECGKAF GDRSTIIQHQ
241 RIHTGENPYE CSKCGKAFSW ISSLTEHQRT HTGENPYECS ECGKVFSRSS SLTEHQRIHS
301 GEKPHECRVC GKGFSRSSSL IIHQRTHTGE KPYKCNDCGK AFCQSSTLIR HQHLHTKELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF391 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 5 nTPM
Expression across tissuesHPA
Tissue
- ovary: 5 nTPM
- testis: 4.6 nTPM
- thyroid gland: 3.8 nTPM
- fallopian tube: 3.7 nTPM
- parathyroid gland: 3.5 nTPM
- cervix: 3.4 nTPM
Single-cell type
- early spermatids: 85 nCPM
- cardiomyocytes: 72 nCPM
- late primary spermatocytes: 55 nCPM
- respiratory ciliated cells: 41 nCPM
- endometrial ciliated cells: 36 nCPM
- fallopian tube ciliated cells: 31 nCPM
Immune cell
- memory B-cell: 1.4 nTPM
- naive B-cell: 1.3 nTPM
- naive CD4 T-cell: 1 nTPM
- MAIT T-cell: 0.7 nTPM
- naive CD8 T-cell: 0.7 nTPM
- memory CD4 T-cell: 0.5 nTPM
Brain region
- cerebral cortex: 14 nTPM
- basal ganglia: 12 nTPM
- white matter: 12 nTPM
- hippocampal formation: 11 nTPM
- amygdala: 9.2 nTPM
- cerebellum: 8.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.58
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF391 as an antibody target. Whether an autoantibody or antibody against ZNF391 could matter depends on whether native ZNF391 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF391 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF391 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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