Seroatlas · Human Serome Atlas

ZNF385D

Zinc finger protein 385D

Also known as: FLJ22419, Z385D_HUMAN, ZNF659

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6B1
Gene: ZNF385D
Ensembl: ENSG00000151789
Chromosome: 3
Canonical length: 395 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q9H6B1|ZNF385D
     1  MRNIMYFGGT CQSPALPALV RPPAPPLQPS LDIKPFLPFP LDTAAAVNLF PNFNAMDPIQ
    61  KAVINHTFGV PLPHRRKQII SCNICQLRFN SDSQAAAHYK GTKHAKKLKA LEAMKNKQKS
   121  VTAKDSAKTT FTSITTNTIN TSSDKTDGTA GTPAISTTTT VEIRKSSVMT TEITSKVEKS
   181  PTTATGNSSC PSTETEEEKA KRLLYCSLCK VAVNSASQLE AHNSGTKHKT MLEARNGSGT
   241  IKAFPRAGVK GKGPVNKGNT GLQNKTFHCE ICDVHVNSET QLKQHISSRR HKDRAAGKPP
   301  KPKYSPYNKL QKTAHPLGVK LVFSKEPSKP LAPRILPNPL AAAAAAAAVA VSSPFSLRTA
   361  PAATLFQTSA LPPALLRPAP GPIRTAHTPV LFAPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF385D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 24 nTPM
testis: 13 nTPM
cerebellum: 11 nTPM
retina: 7.6 nTPM
adipose tissue: 6 nTPM
breast: 5.9 nTPM

Single-cell type

hematopoietic stem cells: 3,544 nCPM
megakaryocyte-erythroid progenitors: 2,487 nCPM
brain excitatory neurons: 1,650 nCPM
retinal amacrine cells: 1,057 nCPM
müller glia: 949 nCPM
retinal horizontal cells: 918 nCPM

Immune cell

neutrophil: 0.2 nTPM
total PBMC: 0.2 nTPM
basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 49 nTPM
midbrain: 21 nTPM
cerebral cortex: 21 nTPM
white matter: 18 nTPM
medulla oblongata: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.65
gnomAD missense Z: 0.63
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF385D as an antibody target. Whether an autoantibody or antibody against ZNF385D could matter depends on whether native ZNF385D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF385D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF385D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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