Seroatlas · Human Serome Atlas

ZNF385C

Zinc finger protein 385C

Also known as: Z385C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q66K41
Gene: ZNF385C
Canonical length: 422 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ZNF385C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q66K41|ZNF385C
     1  MLLGPASGAP SPLLASLPLP TRPLQPPLDF KHLLAFHFNG AAPLSLFPNF STMDPVQKAV
    61  ISHTFGVPSP LKKKLFISCN ICHLRFNSAN QAEAHYKGHK HARKLKAVEA AKSKQRPHTQ
   121  AQDGAVVSPI PTLASGAPGE PQSKVPAAPP LGPPLQPPPT PDPTCREPAH SELLDAASSS
   181  SSSSCPPCSP EPGREAPGPE PAAAAVGSSM SGEGRSEKGH LYCPTCKVTV NSASQLQAHN
   241  TGAKHRWMME GQRGAPRRSR GRPVSRGGAG HKAKRVTGGR GGRQGPSPAF HCALCQLQVN
   301  SETQLKQHMS SRRHKDRLAG KTPKPSSQHS KLQKHAALAV SILKSKLALQ KQLTKTLAAR
   361  FLPSPLPTAA TAICALPGPL ALRPAPTAAT TLFPAPILGP ALFRTPAGAV RPATGPIVLA
   421  PY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF385C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 9.1 nTPM
testis: 6.5 nTPM
retina: 4.1 nTPM
tongue: 3.1 nTPM
hypothalamus: 2.3 nTPM
pituitary gland: 1.7 nTPM

Single-cell type

sertoli cells: 55 nCPM
early spermatids: 47 nCPM
retinal amacrine cells: 26 nCPM
pdcs: 21 nCPM
late spermatids: 18 nCPM
epididymal clear cells: 16 nCPM

Immune cell

plasmacytoid DC: 1.3 nTPM
memory B-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 17 nTPM
hypothalamus: 3.5 nTPM
pons: 3.2 nTPM
cerebral cortex: 2.7 nTPM
white matter: 2.5 nTPM
thalamus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.77

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF385C as an antibody target. Whether an autoantibody or antibody against ZNF385C could matter depends on whether native ZNF385C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF385C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF385C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...