Seroatlas · Human Serome Atlas

ZNF37A

Zinc finger protein 37A

Also known as: KOX21, ZN37A_HUMAN, ZNF37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17032
Gene: ZNF37A
Ensembl: ENSG00000075407
Chromosome: 10
Canonical length: 561 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

561 residues, UniProt reviewed canonical sequence.

>P17032|ZNF37A
     1  MITSQGSVSF RDVTVGFTQE EWQHLDPAQR TLYRDVMLEN YSHLVSVGYC IPKPEVILKL
    61  EKGEEPWILE EKFPSQSHLE LINTSRNYSI MKFNEFNKGG KCFCDEKHEI IHSEEEPSEY
   121  NKNGNSFWLN EDLIWHQKIK NWEQSFEYNE CGKAFPENSL FLVHKRGYTG QKTCKYTEHG
   181  KTCDMSFFIT HQQTHPRENH YGNECGENIF EESILLEHQS VYPFSQKLNL TPIQRTHSIN
   241  NIIEYNECGT FFSEKLVLHL QQRTHTGEKP YECHECGKTF TQKSAHTRHQ RTHTGGKPYE
   301  CHECGKTFYK NSDLIKHQRI HTGERPYGCH ECGKSFSEKS TLTQHQRTHT GEKPYECHEC
   361  GKTFSFKSVL TVHQKTHTGE KPYECYACGK AFLRKSDLIK HQRIHTGEKP YECNECGKSF
   421  SEKSTLTKHL RTHTGEKPYE CIQCGKFFCY YSGFTEHLRR HTGEKPFGCN ECGKTFRQKS
   481  ALIVHQRTHI RQKPYGCNQC GKSFCVKSKL IAHHRTHTGE KPYECNVCGK SFYVKSKLTV
   541  HQRIHLGRNP INVVNEGNYS G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF37A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

retina: 15 nTPM
parathyroid gland: 9.1 nTPM
pancreas: 7.7 nTPM
thyroid gland: 7.6 nTPM
salivary gland: 7.1 nTPM
endometrium: 6.7 nTPM

Single-cell type

breast lactating cells: 2.4 nCPM
epicardial cells: 2.3 nCPM
early primary spermatocytes: 2.1 nCPM
cholangiocytes: 2 nCPM
parietal cells: 1.8 nCPM
megakaryocyte-erythroid progenitors: 1.7 nCPM

Immune cell

NK-cell: 2.7 nTPM
naive B-cell: 2.6 nTPM
non-classical monocyte: 2.3 nTPM
naive CD4 T-cell: 2.1 nTPM
MAIT T-cell: 2 nTPM
memory CD4 T-cell: 1.8 nTPM

Brain region

cerebellum: 40 nTPM
white matter: 35 nTPM
hypothalamus: 34 nTPM
cerebral cortex: 34 nTPM
hippocampal formation: 31 nTPM
thalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: -0.08
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF37A as an antibody target. Whether an autoantibody or antibody against ZNF37A could matter depends on whether native ZNF37A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF37A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF37A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...