ZNF367
Zinc finger protein 367
Also known as: FLJ33970, ZN367_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7RTV3
- Gene
- ZNF367
- Ensembl
- ENSG00000165244
- Chromosome
- 9
- Canonical length
- 350 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables DNA-binding transcription factor activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
350 residues, UniProt reviewed canonical sequence.
>Q7RTV3|ZNF367
1 MIRGFEAPMA ENPPPPPPPV IFCHDSPKRV LVSVIRTTPI KPTCGGGGEP EPPPPLIPTS
61 PGFSDFMVYP WRWGENAHNV TLSPGAAGAA ASAALPAAAA AEHSGLRGRG APPPAASASA
121 AASGGEDEEE ASSPDSGHLK DGIRRGRPRA DTVRDLINEG EHSSSRIRCN ICNRVFPREK
181 SLQAHKRTHT GERPYLCDYP DCGKAFVQSG QLKTHQRLHT GEKPFVCSEN GCLSRFTHAN
241 RHCPKHPYAR LKREEPTDTL SKHQAADNKA AAEWLARYWE MREQRTPTLK GKLVQKADQE
301 QQDPLEYLQS DEEDDEKRGA QRRLQEQRER LHGALALIEL ANLTGAPLRQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF367 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 25 nTPM
- liver: 10 nTPM
- thymus: 8.1 nTPM
- testis: 5.7 nTPM
- tonsil: 4.4 nTPM
- lymph node: 4.2 nTPM
Single-cell type
- erythrocyte progenitors: 104 nCPM
- platelets: 83 nCPM
- neutrophil progenitors: 76 nCPM
- monocyte progenitors: 74 nCPM
- megakaryocyte progenitors: 50 nCPM
- migrating cytotrophoblasts: 41 nCPM
Immune cell
- T-reg: 0.3 nTPM
- memory CD8 T-cell: 0.2 nTPM
- naive CD4 T-cell: 0.2 nTPM
- naive CD8 T-cell: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
Brain region
- white matter: 5.2 nTPM
- medulla oblongata: 3.3 nTPM
- pons: 3 nTPM
- cerebellum: 2.8 nTPM
- thalamus: 2.8 nTPM
- basal ganglia: 2.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.4
- gnomAD pLI
- 0.91
- gnomAD missense Z
- 2.65
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF367 as an antibody target. Whether an autoantibody or antibody against ZNF367 could matter depends on whether native ZNF367 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF367 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF367 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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