Seroatlas · Human Serome Atlas

ZNF362

Zinc finger protein 362

Also known as: FLJ25476, lin-29, RN, ZN362_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T0B9
Gene: ZNF362
Ensembl: ENSG00000160094
Chromosome: 1
Canonical length: 420 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q5T0B9|ZNF362
     1  MSRSSPSGKG HSRMAEPRFN NPYFWPPPPT MPSQLDNLVL INKIKEQLMA EKIRPPHLPP
    61  TSASSQQPLL VPPAPAESSQ AVMSLPKLQQ VPGLHPQAVP QPDVALHARP ATSTVTGLGL
   121  STRTPSVSTS ESSAGAGTGT GTSTPSTPTT TSQSRLIASS PTLISGITSP PLLDSIKTIQ
   181  GHGLLGPPKS ERGRKKIKAE NPGGPPVLVV PYPILASGET AKEGKTYRCK VCPLTFFTKS
   241  EMQIHSKSHT EAKPHKCPHC SKSFANASYL AQHLRIHLGV KPYHCSYCDK SFRQLSHLQQ
   301  HTRIHTGDRP YKCPHPGCEK AFTQLSNLQS HQRQHNKDKP YKCPNCYRAY SDSASLQIHL
   361  SAHAIKHAKA YCCSMCGRAY TSETYLMKHM SKHTVVEHLV SHHSPQRTES PGIPVRISLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF362 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 31 nTPM
cerebellum: 22 nTPM
cervix: 20 nTPM
endometrium: 20 nTPM
heart muscle: 19 nTPM
prostate: 19 nTPM

Single-cell type

microglia: 66 nCPM
retinal horizontal cells: 54 nCPM
thyrotrophs: 52 nCPM
oocytes: 51 nCPM
pituitary stem cells: 47 nCPM
oligodendrocyte progenitor cells: 44 nCPM

Immune cell

plasmacytoid DC: 3.6 nTPM
naive B-cell: 3 nTPM
eosinophil: 2.6 nTPM
non-classical monocyte: 2 nTPM
basophil: 1.9 nTPM
classical monocyte: 1.9 nTPM

Brain region

cerebral cortex: 54 nTPM
medulla oblongata: 44 nTPM
amygdala: 44 nTPM
thalamus: 42 nTPM
basal ganglia: 41 nTPM
cerebellum: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.94
gnomAD missense Z: 2.73
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF362 as an antibody target. Whether an autoantibody or antibody against ZNF362 could matter depends on whether native ZNF362 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF362 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF362 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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