Seroatlas · Human Serome Atlas

ZNF354C

Zinc finger protein 354C

Also known as: KID3, Z354C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86Y25
Gene: ZNF354C
Ensembl: ENSG00000177932
Chromosome: 5
Canonical length: 554 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of sprouting angiogenesis. Located in cytoplasm; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

554 residues, UniProt reviewed canonical sequence.

>Q86Y25|ZNF354C
     1  MAVDLLSAQE PVTFRDVAVF FSQDEWLHLD SAQRALYREV MLENYSSLVS LGIPFSMPKL
    61  IHQLQQGEDP CMVEREVPSD TRLGFKTWLE TEALPHRQDI FIEETSQGMV KKESIKDGHW
   121  DINFEEAVEF ESEIEEEQEK KPLRQMIDSH EKTISEDGNH TSLELGKSLF TNTALVTQQS
   181  VPIERIPNMY YTFGKDFKQN FDLMKCFQIY PGGKPHICNE CGKSFKQNLH LIEHQRIHTG
   241  EKPYKCNECE KTFSHRSSLL SHQRIHTGEK PYKCNECEKA FSNSSTLIKH LRVHTGEKPY
   301  RCRECGKAFS QCSTLTVHQR IHTGEKLYKC GECEKAFNCR AKLHRHQRIH TGEKPYKCSE
   361  CGKGYSQFTS LAEHQRFHTG EQLYTCLECG RTFTRIVTLI EHQRIHTGQK PYQCNECEKA
   421  FNQYSSFNEH RKIHTGEKLY TCEECGKAFG CKSNLYRHQR IHTGEKPYQC NQCGKAFSQY
   481  SFLTEHERIH TGEKLYKCME CGKAYSYRSN LCRHKKVHTK EKLYKWKEYG KPFICSSSLT
   541  QYQRFFKGDK AYEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF354C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

ovary: 6 nTPM
retina: 5.9 nTPM
endometrium: 4.8 nTPM
thyroid gland: 4.4 nTPM
thymus: 4.1 nTPM
cerebellum: 4 nTPM

Single-cell type

adipocytes: 36 nCPM
cardiomyocytes: 30 nCPM
retinal amacrine cells: 23 nCPM
fibro-adipogenic progenitors: 23 nCPM
retinal bipolar cells: 23 nCPM
bergmann glia: 22 nCPM

Immune cell

memory CD4 T-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.6 nTPM
non-classical monocyte: 0.6 nTPM
gdT-cell: 0.5 nTPM
MAIT T-cell: 0.5 nTPM

Brain region

cerebellum: 14 nTPM
white matter: 9.9 nTPM
basal ganglia: 8.7 nTPM
midbrain: 8.3 nTPM
thalamus: 8.1 nTPM
medulla oblongata: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF354C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF354C as an antibody target. Whether an autoantibody or antibody against ZNF354C could matter depends on whether native ZNF354C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF354C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF354C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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